To mimic an ECM, scientists used a matrix formed by different collagen concentrations and analyzed migration trajectories of primary human cytotoxic T lymphocytes. Different migration patterns were observed and could be grouped into three motility types: slow, fast, and mixed.
Celularity, Inc. announced that the first patient was dosed in its Phase I clinical study of human placental hematopoietic stem cell-derived natural killer cells (CYNK-001) in adults with recurrent glioblastoma multiforme.
[Celularity, Inc. (PR Newswire Association LLC.)]
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Researchers demonstrated that CCL7 facilitated anti-PD-1 therapy for the KrasLSL−G12D/+Tp53fl/fl and the KrasLSL−G12D/+Lkb1fl/fl NSCLC mouse models by recruiting conventional DC 1 into the TME to promote T cell expansion.
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Zhang, M., Yang, W., Wang, P., Deng, Y., Dong, Y.-T., Liu, F.-F., Huang, R., Zhang, P., Duan, Y.-Q., Liu, X.-D., Lin, D., Chu, Q., & Zhong, B. (2020). CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nature Communications, 11(1), 6119. https://doi.org/10.1038/s41467-020-19973-6 Cite
Scientists report a one‐step CRISPR/Cas9 KI methodology to combine the insertion of human germline immunoglobulin heavy and light chains at their endogenous loci in mice.
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Wang, X., Ray, R., Kratochvil, S., Melzi, E., Lin, Y.-C., Giguere, S., Xu, L., Warner, J., Cheon, D., Liguori, A., Groschel, B., Phelps, N., Adachi, Y., Tingle, R., Wu, L., Crotty, S., Kirsch, K. H., Nair, U., Schief, W. R., & Batista, F. D. (2020). Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors. The EMBO Journal, n/a(n/a), e105926. https://doi.org/10.15252/embj.2020105926 Cite
Oral administration of β-elemene, contained in various foodstuffs, downregulated expressions of inflammatory cytokines and increased Foxp3+CD4+ T cells in adipose tissue of obese mice.
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Zhou, Y., Takano, T., Wang, Y., Li, X., Wang, R., Wakatsuki, Y., Nakajima-Adachi, H., Tanokura, M., Miyakawa, T., & Hachimura, S. (2020). Intestinal Regulatory T Cell Induction by β-Elemene Alleviates the Formation of Fat Tissue-Related Inflammation. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101883 Cite
The authors discuss natural killer cells’ cytotoxicity and modulation function in gastrointestinal cancer and the current application in clinical therapy.
The authors showed that in preclinical autoimmunity and established systemic lupus erythematosus, plasmacytoid dendritic cells were not effector cells, had lost capacity for Toll-like-receptor-mediated cytokine production and did not induce T cell activation.
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Psarras, A., Alase, A., Antanaviciute, A., Carr, I. M., Md Yusof, M. Y., Wittmann, M., Emery, P., Tsokos, G. C., & Vital, E. M. (2020). Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity. Nature Communications, 11(1), 6149. https://doi.org/10.1038/s41467-020-19918-z Cite
Food insecurity was associated with increased activation of CD4+ and CD8+ T-cells, increased senescence of CD8+ T-cells, and decreased co-stimulation of CD4+ and CD8+ T-cells
[Clinical Infectious Diseases]
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Peters, B. A., Sheira, L. A., Hanna, D. B., Qi, Q., Sharma, A., Adedimeji, A., Wilson, T., Merenstein, D., Tien, P. C., Cohen, M., Wentz, E. L., Kinslow, J., Landay, A. L., & Weiser, S. D. (n.d.). Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa1771 Cite
Researchers recapitulated the immunosuppression observed in glioblastoma patients in the C57BL/6 mouse and investigated the aetiology of low CD4 T-cell counts.
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Ayasoufi, K., Pfaller, C. K., Evgin, L., Khadka, R. H., Tritz, Z. P., Goddery, E. N., Fain, C. E., Yokanovich, L. T., Himes, B. T., Jin, F., Zheng, J., Schuelke, M. R., Hansen, M. J., Tung, W., Parney, I. F., Pease, L. R., Vile, R. G., & Johnson, A. J. (n.d.). Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators. Brain. https://doi.org/10.1093/brain/awaa343 Cite
To clarify the role of CD4+ regulatory T cells in bladder cancer, scientists investigated the frequency of these cells in tumor draining lymph nodes of 50 patients with bladder cancer who underwent radical cystectomy using flow cytometry method.
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Riddell’s lab is working to make CAR T-cell therapies even better and expand the repertoire of cancers it can treat. Based out of the Hutch’s new Steam Plant facility, he and his colleagues are zeroing in on multiple myeloma as the next likely new target for the approach.
[Fred Hutchinson Cancer Research Center]
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