LC3B Upregulation by NANOG Promotes Immune Resistance and Stem-Like Property through Hyperactivation of EGFR Signaling in Immune-Refractory Tumor Cells

Scientists report that the emergence of refractory phenotypes was highly associated with an aberrant macroautophagic/autophagic state of NANOG+ tumor cells and that the autophagic phenotype arises through transcriptional induction of MAP1LC3B/LC3B by NANOG.
[Autophagy]
Kim, S., Cho, H., Hong, S.-O., Oh, S. J., Lee, H.-J., Cho, E., Woo, S. R., Song, J. S., Chung, J.-Y., Son, S. W., Yoon, S. M., Jeon, Y.-M., Jeon, S., Yee, C., Lee, K.-M., Hewitt, S. M., Kim, J.-H., Song, K.-H., & Kim, T. W. (2020). LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1805214 Cite
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Immediate Intracoronary Delivery of Human Umbilical Cord Mesenchymal Stem Cells Reduces Myocardial Injury by Regulating the Inflammatory Process via Cell-Cell Contact with T Lymphocytes

To investigate the effects of human umbilical cord mesenchymal stem cell (HUCMSC) delivery on the acute inflammatory stage of ischemia reperfusion injury, the authors transplanted HUCMSCs or HUCMSCs with cyclosporin A via the coronary artery simultaneously during ischemia reperfusion in pigs.
[Stem Cells and Development]
Liu, C., Kang, L.-N., Chen, F., Mu, D., Shen, S., Wang, K., Hu, J.-X., Xie, J., & Xu, B. (2020). Immediate intracoronary delivery of human umbilical cord mesenchymal stem cells reduces myocardial injury by regulating the inflammatory process via cell-cell contact with T lymphocytes. Stem Cells and Development. https://doi.org/10.1089/scd.2019.0264 Cite
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Celularity Announces the Activation of First California Clinical Trial Site following CIRM Grant Award to Advance Treatments for COVID-19

Celularity announced that it has been awarded a $750,000 COVID-19 Project grant by the California Institute for Regenerative Medicine (CIRM), one of the three clinical awards targeting the coronavirus. This grant will support California Institutions participating in the Phase I/II clinical trial of human placental hematopoietic stem cell derived natural killer cells for the treatment of adults with COVID-19.
[Celularity Inc.]
Press Release

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Physioxia Enhances T Cell Development Ex Vivo from Human Hematopoietic Stem and Progenitor Cells

Investigators report that physiologically relevant oxygen concentration, an important environmental thymic factor promotes differentiation of cord blood CD34+ cells into progenitor T cells in serum‐free and feeder‐free culture system.
[Stem Cells]
Shin, D., Huang, X., Gil, C.-H., Aljoufi, A., Ropa, J., & Broxmeyer, H. E. (n.d.). Physioxia enhances T cell development ex vivo from human hematopoietic stem and progenitor cells. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3259 Cite
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A Peripheral Immune Signature of Responsiveness to PD-1 Blockade in Patients with Classical Hodgkin Lymphoma

Investigators utilized the complementary approaches of T cell receptor sequencing and cytometry by time-of-flight analysis to obtain a peripheral immune signature of responsiveness to PD-1 blockade in 56 patients treated in the CheckMate 205 Phase II clinical trial
[Nature Medicine]
Cader, F. Z., Hu, X., Goh, W. L., Wienand, K., Ouyang, J., Mandato, E., Redd, R., Lawton, L. N., Chen, P.-H., Weirather, J. L., Schackmann, R. C. J., Li, B., Ma, W., Armand, P., Rodig, S. J., Neuberg, D., Liu, X. S., & Shipp, M. A. (2020). A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma. Nature Medicine, 1–12. https://doi.org/10.1038/s41591-020-1006-1 Cite
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Inhibition of Bruton’s Tyrosine Kinase Interferes with Pathogenic B-Cell Development in Inflammatory CNS Demyelinating Disease

Using mouse models of multiple scelrosis, investigators determined that evobrutinib, the first Burton’s tyrosine kinase inhibiting molecule being developed, dose-dependently inhibited antigen-triggered activation and maturation of B cells as well as their release of pro-inflammatory cytokines.
[Acta Neuropathologica]
Full Article

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Cosmc Controls B Cell Homing

Scientists report that B cell-specific deletion of the X-linked gene, Cosmc, and the consequent decrease of protein O-glycosylation, induced developmental blocks of mouse B cells.
[Nature Communications]
Zeng, J., Eljalby, M., Aryal, R. P., Lehoux, S., Stavenhagen, K., Kudelka, M. R., Wang, Y., Wang, J., Ju, T., von Andrian, U. H., & Cummings, R. D. (2020). Cosmc controls B cell homing. Nature Communications, 11(1), 3990. https://doi.org/10.1038/s41467-020-17765-6 Cite
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Antibody-Secreting Cell Destiny Emerges during the Initial Stages of B-Cell Activation

Scientists investigated B cell fate programming and heterogeneity during anti-body secreting cells (ASCs) differentiation using T cell-independent models. They found that maximal ASC induction required at least eight cell divisions in vivo, with BLIMP-1 being required for differentiation at division eight.
[Nature Communications]
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Coordinated Co-Migration of CCR10+ Antibody-Producing B Cells with Helper T Cells for Colonic Homeostatic Regulation

The authors report the first evidence that the gut-homing chemokine receptor CCR10+ IgA antibody-secreting B cells formed conjugates with helper T cells, preferentially regulatory T cells, at their differentiation sites of gut-associated lymphoid organs for their coordinated co-localization into the colon to promote local homeostasis.
[Mucosal Immunology]
Zhao, L., Hu, S., Davila, M. L., Yang, J., Lin, Y.-D., Albanese, J. M., Lo, Y., Wang, Y., Kennett, M. J., Liu, Q., & Xiong, N. (2020). Coordinated co-migration of CCR10 + antibody-producing B cells with helper T cells for colonic homeostatic regulation. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-020-0333-3 Cite
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Orally Administered Exosomes Suppress Mouse Delayed-Type Hypersensitivity by Delivering miRNA-150 to Antigen-Primed Macrophage APC Targeted by Exosome-Surface Anti-Peptide Antibody Light Chains

Ovalbumin-immunized B1a cells produced an exosome subpopulation, originally coated with antigen-specific free-light chains, that could be rendered suppressive by in vitro association with miRNA-150.
[International Journal of Molecular Sciences]
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Immune-Mobilising Monoclonal T Cell Receptors Mediate Specific and Rapid Elimination of Hepatitis B-Infected Cells

The ability of immune mobilising monoclonal T cell receptors Against Virus-envelope to activate and redirect polyclonal T cells towards cells containing integrated HBV and cells infected with hepatitis B virus was assessed using cytokine secretion assays and imaging‐based killing assays.
[Hepatology]
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Physioxia Enhances T Cell Development Ex Vivo from Human Hematopoietic Stem and Progenitor Cells

Scientists report that physiologically relevant oxygen concentration, an important environmental thymic factor promotes differentiation of cord blood CD34+ cells into progenitor T cells in serum‐free and feeder‐free culture system. This effect was enhanced by a potent reducing and antioxidant agent, ascorbic acid.
[Stem Cells]
Shin, D., Huang, X., Gil, C.-H., Aljoufi, A., Ropa, J., & Broxmeyer, H. E. (n.d.). Physioxia enhances T cell development ex vivo from human hematopoietic stem and progenitor cells. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3259 Cite
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