B2M Gene Expression Shapes the Immune Landscape of Lung Adenocarcinoma and Determines the Response to Immunotherapy

Scientists performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer patients and found that epigenetic downregulation of B2M was common.
[Immunology]
Zhao, Y., Cao, Y., Chen, Y., Wu, L., Hang, H., Jiang, C., & Zhou, X. (n.d.). B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy. Immunology, n/a(n/a). https://doi.org/10.1111/imm.13384 Cite
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Blocking Siglec-10hi Tumor-Associated Macrophages Improves Anti-Tumor Immunity and Enhances Immunotherapy for Hepatocellular Carcinoma

Immunohistochemistry and flow cytometry were performed to detect the characteristics of sialic acid-binding immunoglobulin-like lectin 10high (Siglec-10hi) tumor-associated macrophages and explore their impact on the tumor microenvironment of hepatocellular carcinoma.
[Experimental Hematology & Oncology]
Xiao, N., Zhu, X., Li, K., Chen, Y., Liu, X., Xu, B., Lei, M., Xu, J., & Sun, H.-C. (2021). Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma. Experimental Hematology & Oncology, 10(1), 36. https://doi.org/10.1186/s40164-021-00230-5 Cite
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Imaging CAR T-Cell Kinetics in Solid Tumors: Translational Implications

Scientists conducted dual tumor and T-cell imaging by use of a bioluminescent reporter and positron emission tomography in clinically relevant mouse models of pleural mesothelioma and non-small cell lung cancer.
[Molecular Therapy-Oncolytics]
Skovgard, M. S., Hocine, H. R., Saini, J. K., Moroz, M., Bellis, R. Y., Banerjee, S., Morello, A., Ponomarev, V., Villena-Vargas, J., & Adusumilli, P. S. (2021). Imaging CAR T-Cell Kinetics in Solid Tumors: Translational Implications. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.06.006 Cite
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Immune Modulation via Adipose Derived Mesenchymal Stem Cells Is Driven by Donor Sex In Vitro

The authors examined the potency and functionality of both female and male adipose derived mesenchymal stem cells in order to gain further insights into donor selection.
[Scientific Reports]
Mckinnirey, F., Herbert, B., Vesey, G., & McCracken, S. (2021). Immune modulation via adipose derived Mesenchymal Stem cells is driven by donor sex in vitro. Scientific Reports, 11(1), 12454. https://doi.org/10.1038/s41598-021-91870-4 Cite
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Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products

Scientists discuss the progress made in induced pluripotent stem cells (iPSC)-derived T cells and provides a roadmap for the development of CAR iPSC-derived T cells and off-the-shelf T-iPSCs.
[Pharmaceutical Research]
Sadeqi Nezhad, M., Abdollahpour-Alitappeh, M., Rezaei, B., Yazdanifar, M., & Seifalian, A. M. (2021). Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products. Pharmaceutical Research. https://doi.org/10.1007/s11095-021-03067-z Cite
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Therapeutic Effect of IL1β Priming Tonsil Derived-Mesenchymal Stem Cells in Osteoporosis

IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulate both osteoclastogenesis and osteoblastogenesis.
[Tissue Engineering and Regenerative Medicine]
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T-Regulatory Cells Predict Clinical Outcome in Soft Tissue Sarcoma Patients: A Clinico-Pathological Study

Investigators analyzed tumor-infiltrating lymphocytes and immune checkpoint molecules in soft tissue sarcomas, and assessed their prognostic impact regarding local recurrence, distant metastasis, and overall survival.
[British Journal of Cancer]
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Phase I/II Clinical Trial of Adoptive Cell Transfer of Sorted Specific T Cells for Metastatic Melanoma Patients

Scientists reported results from a phase I/II clinical trial in which six metastatic HLA-A2 melanoma patients received autologous antigen-specific T-cells produced from peripheral blood mononuclear cells, after peptide stimulation in vitro, followed by sorting with HLA-peptide multimers and amplification.
[Cancer Immunology Immunotherapy]
Dréno, B., Khammari, A., Fortun, A., Vignard, V., Saiagh, S., Beauvais, T., Jouand, N., Bercegay, S., Simon, S., Lang, F., & Labarrière, N. (2021). Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-021-02961-0 Cite
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TCF1 in T Cell Immunity: A Broadened Frontier

Scientists summarize the key findings on TCF1 across the fields of T cell immunity and reflect on the possibility of exploring TCF1 and its downstream transcriptional programmes as therapeutic targets for improving antiviral and antitumour immunity.
[Nature Reviews Immunology]
Zhao, X., Shan, Q., & Xue, H.-H. (2021). TCF1 in T cell immunity: a broadened frontier. Nature Reviews Immunology, 1–11. https://doi.org/10.1038/s41577-021-00563-6 Cite
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Distinct Antibody and Memory B Cell Responses in SARS-CoV-2 Naïve and Recovered Individuals Following mRNA Vaccination

Researchers showed that the SARS-CoV-2 envelope protein alone is able to cause acute respiratory distress syndrome-like damages in vitro and in vivo.
[Science Immunology]
Goel, R. R., Apostolidis, S. A., Painter, M. M., Mathew, D., Pattekar, A., Kuthuru, O., Gouma, S., Hicks, P., Meng, W., Rosenfeld, A. M., Dysinger, S., Lundgreen, K. A., Kuri-Cervantes, L., Adamski, S., Hicks, A., Korte, S., Oldridge, D. A., Baxter, A. E., Giles, J. R., … Wherry, E. J. (2021). Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination. Science Immunology, 6(58). https://doi.org/10.1126/sciimmunol.abi6950 Cite
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Structural Specificities of Cell Surface β-Glucan Polysaccharides Determine Commensal Yeast Mediated Immuno-Modulatory Activities

MGCP, in contrast to previously identified microbial cell surface polysaccharides, through a Dectin1-Cox2 signaling axis in dendritic cells, facilitates regulatory T cell induction from naïve T cells.
[Nature Communications]
Lee, C., Verma, R., Byun, S., Jeun, E.-J., Kim, G.-C., Lee, S., Kang, H.-J., Kim, C. J., Sharma, G., Lahiri, A., Paul, S., Kim, K. S., Hwang, D. S., Iwakura, Y., Speciale, I., Molinaro, A., De Castro, C., Rudra, D., & Im, S.-H. (2021). Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities. Nature Communications, 12(1), 3611. https://doi.org/10.1038/s41467-021-23929-9 Cite
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