TGM2-Mediated Serotonylation of GPX4 Confers Ferroptosis Resistance to Promote Gastric Tumorigenesis

Using untargeted plasma metabolomics, researchers revealed that the level of serotonin (5-HT) is significantly elevated in gastric cancer (GC) patients. Functionally, 5-HT treatment dramatically promoted GC cell proliferation and tumor growth in a dose-dependent manner.