cancer stem cells

[British Journal of Cancer] The authors investigated the role of acetylsalicylic acid in chemotherapy/chemoprevention in human oesophageal squamous cell carcinoma (ESCC) cell lines and an N-nitrosomethylbenzylamine-induced rat ESCC carcinogenesis model.

[Journal of Cancer Research and Clinical Oncology] Musashi-1 was artificially downregulated in MCF-7 breast cancer cells and implications for cancer stem cell markers, cell apoptosis and apoptosis regulator p21, proliferation and radiation response were analyzed via flow cytometry and colony formation.

[Toxicology Letters] Since inorganic arsenic targets prostatic stem cells, researchers hypothesized that arsenic-transformed stem cells show an impaired TLR3-associated anti-tumor pathway and, therefore, are unresponsive to polyinosinic:polycytidylic acid activation.

[Stem Cells and Development] Scientists reported that reduced death-associated protein kinase 1 (DAPK1) expression promoted stem cell-like characteristics of prostate cancer cells through activating zinc finger E-box binding homeobox-1 (ZEB1) via Hippo/YAP signaling pathway.

[Cell Death & Disease] Scientists demonstrated that afatinib induced mTORC1 suppression-mediated autophagy in head and neck squamous cell carcinoma cells.

[Science Advances] Scientists demonstrated that NAD+ metabolism enabled acute myeloid leukemia (AML) to evade apoptosis. They integrated whole-genome CRISPR screening and pan-cancer genetic dependency mapping to identify NAMPT and NMNAT1 as AML dependencies governing NAD+ biosynthesis.