Human Prostate Epithelial Cells and Prostate-Derived Stem Cells Malignantly Transformed In Vitro with Sodium Arsenite Show Impaired Toll Like Receptor -3 (TLR3)-Associated Anti-Tumor Pathway

Since inorganic arsenic targets prostatic stem cells, researchers hypothesized that arsenic-transformed stem cells show an impaired TLR3-associated anti-tumor pathway and, therefore, are unresponsive to polyinosinic:polycytidylic acid activation.