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epithelial cells

Caspase-9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis

[Molecular Cancer Research] A transgenic mouse model expressing human Caspase-9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive MDSCs in contrast to wild-type mice.

Generation of Human Embryonic Stem Cell-Derived Lung Organoids

[STAR Protocols] This protocol describes how to generate lung organoids from human embryonic stem cells. Lung organoids form by self-assembly in Matrigel and contain lung epithelial cell types.

Diosgenin Derivatives Developed from Pd(ii) Catalysed Dehydrogenative Coupling Exert an Effect on Breast Cancer Cells by Abrogating Their Growth and Facilitating Apoptosis via Regulating...

[Dalton Transactions] Based on the pharmacological importance of diosgenin, the obtained derivatives were exposed to study their effect on breast cancer cells where they significantly reduced the growth of cancer cells and left non-malignant breast epithelial cells unaffected.

Nrf2 and NF-κB/NLRP3 Inflammasome Pathways Are Involved in Prototheca bovis Infections of Mouse Mammary Gland Tissue and Mammary Epithelial Cells

[Free Radical Biology and Medicine] Investigators characterized how Prototheca bovis induced inflammatory responses in mouse mammary gland tissue and mammary epithelial cells.

Selection of a Novel Strain of Christensenella minuta as a Future Biotherapy for Crohn’s Disease

[Scientific Reports] Scientists described a complete screening process combining in vitro and in vivo assays to conduct a rational selection of a live strain of Christensenella minuta with strong immunomodulatory properties.

Secreted NF-κB Suppressive Microbial Metabolites Modulate Gut Inflammation

[Cell Reports] Researchers identified five Clostridium strains that suppressed immune-mediated NF-κB activation in epithelial cell lines, peripheral blood mononuclear cells, and gut epithelial organoids from healthy human subjects and patients with inflammatory bowel disease.

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