Lung Epithelial and Endothelial Damage, Loss of Tissue Repair, Inhibition of Fibrinolysis, and Cellular Senescence in Fatal COVID-19

Lung autopsy samples from 18 patients with fatal COVID-19, with symptom onset-to-death times ranging from 3 to 47 days, and antemortem plasma samples from 6 of these cases were evaluated using deep sequencing of SARS-CoV-2 RNA, multiplex plasma protein measurements, and pulmonary gene expression and imaging analyses.
[Science Translational Medicine]
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Aluminum Induced Intestinal Dysfunction via Mechanical, Immune, Chemical and Biological Barriers

Aluminum treatment can regulate intestinal composition and bio-enzyme activity, impairing the function of chemical barrier.
[Chemosphere]
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Fluid Flow Exposure Promotes Epithelial-to-Mesenchymal Transition and Adhesion of Breast Cancer Cells to Endothelial Cells

Researchers showed that fluid forces on the order of 1 Pa promoted epithelial-to-mesenchymal transition and adhesion of breast cancer cells to an endothelial monolayer and identified biomarkers were distinctly expressed in patient populations.
[Breast Cancer Research]
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Cis-Acting Lnc-Cxcl2 Restrains Neutrophil-Mediated Lung Inflammation by Inhibiting Epithelial Cell CXCL2 Expression in Virus Infection

Scientists identified an inducible lncRNA in the Cxcl2 gene locus, lnc-Cxcl2, which could selectively inhibit Cxcl2 expression in mouse lung epithelial cells but not in macrophages.
[Proceedings of the National Academy of Sciences of the United States of America]
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CCCTC-Binding Factor Transcriptionally Regulates Galectin-7 and Activates the JNK/STAT3 Axis to Aggravate Bronchial Epithelial Cell Injury

Human bronchial epithelial cells BEAS-2B were stimulated with transforming growth factor-β1 at a concentration of 10 ng/mL, and CCCTC-binding factor (CTCF) overexpression plasmid and CTCF small interfering RNA were transfected into the cells.
[Pediatric Pulmonology]
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In Vitro Genotoxicity of Dibutyl Phthalate on A549 Lung Cells at Air-Liquid Interface in Exposure Concentrations Relevant at Workplaces

While in vitro studies were often based on submerged exposures, this study aimed to expose A549 alveolar epithelial cells at the air-liquid interface (ALI) to unravel the genotoxic and oxidative stress-inducing potential of dibutyl phthalate (DBP) with concentrations relevant at occupational settings.
[Environmental and Molecular Mutagenesis]
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In Vitro Impact Preliminary Assessment of Airborne Particulate from Metalworking and Woodworking Industries

3D airway epithelial tissues allowed to mimic exposure conditions in vitro, generated human-relevant toxicology data, and allowed to elucidate the mode of action of pollutants.
[Scientific Reports]
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Integrated Analysis of Dysregulated microRNA and mRNA Expression in Intestinal Epithelial Cells Following Ethanol Intoxication and Burn Injury

Investigators performed an integrated analysis of miRNA and RNA sequencing data to identify a network of interactions within small intestinal epithelial cells (IECs) which could promote gut barrier disruption.
[Scientific Reports]
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CCL11 Exacerbates Colitis and Inflammation-Associated Colon Tumorigenesis

Scientists showed that CCL11 was involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis and in colon tumorigenesis in the azoxymethane-DSS model of colitis-associated carcinogenesis.
[Oncogene]
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Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo

As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.
[Evidence-Based Complementary and Alternative Medicine]
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Culture with Apically Applied Healthy or Disease Sputum Alters the Airway Surface Liquid Proteome and Ion Transport across Human Bronchial Epithelial Cells.

Researchers investigated how culture of normal human bronchial epithelial cells with apically applied secretions from healthy or disease lungs affected epithelial function with a view to providing better in vitro models of the in vivo environment.
[American Journal of Physiology-Cell Physiology]
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