Continue reading “Neutrophil Extracellular Traps Amplify Neutrophil Recruitment and Inflammation in Neutrophilic Asthma by Stimulating the Airway Epithelial Cells to Activate the TLR4/NF-κB Pathway and Secrete Chemokines”
Formation of neutrophil extracellular traps (NETs) and neutrophil swarming was seen in a mouse model of neutrophilic asthma. Additionally, NETs were found to stimulate airway cells to express CXCL1, CXCL2, and CXCL8 via the TLR4/NF-κB pathway, which recruits neutrophils to the inflammation site.
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Aging | Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemokines - Full Text. (n.d.). Retrieved August 7, 2020, from https://www.aging-us.com/article/5f2427ad6c2ca900075aeb68/text Cite
The addition of chelerythrine significantly inhibited the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 μM, but not on androgen-dependent prostate cancer LNCaP cells as well as normal prostate epithelial cell line PrEC cells.
[Molecular and Cellular Biochemistry]
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Scientists found that deletion of Erk1/2 in intestinal epithelial cells at embryonic stages resulted in an unexpected increase in cell proliferation and migration, expansion of intestinal stem cells and formation of polyp-like structures, leading to postnatal death.
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ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation | Development. (n.d.). Retrieved August 7, 2020, from https://dev.biologists.org/content/early/2020/07/30/dev.185678 Cite
In the wound healing assay, berberine exhibited the ability to promote cell migration, indicating that berberine could probably recover the function of intestinal epithelial cells when the intestinal epithelial barrier was damaged by the peritoneal dialysis fluid.
[Journal of Ethnopharmacology]
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Zhang, D., Jiang, L., Wang, M., Jin, M., Zhang, X., Liu, D., Wang, Z., Yang, L., & Xu, X. (2020). Berberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration. Journal of Ethnopharmacology, 113206. https://doi.org/10.1016/j.jep.2020.113206 Cite
Scientists showed that AU-rich element RNA-binding protein 1 was an important inducer of the epithelial-to-mesenchymal transition process through stabilization of SNAIL1 and TWIST1 and the consequent promotion of breast cancer stem cells.
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AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1 | Oncogenesis. (n.d.). Retrieved August 6, 2020, from https://www.nature.com/articles/s41389-020-00255-1 Cite
Scientists investigated mammary epithelial cell phenotypes and metabolic profiles on animal breast extracellular matrix-derived tissue matrix gel, Col I, and Matrigel. Atomic force microscopy, fluorescence microscopy, acini formation assay, differentiation experiments, spatial migration/invasion assays, proliferation assay, and nuclear magnetic resonance spectroscopy were used to examine biological phenotypes and metabolic changes.
[Breast Cancer Research]
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Distinct phenotypes of cancer cells on tissue matrix gel | Breast Cancer Research | Full Text. (n.d.). Retrieved August 6, 2020, from https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-01321-7 Cite
Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
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Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
Scientists report a rationally designed adeno-associated virus 6 capsid that demonstrates efficiency in lung epithelial cell transduction based on imaging and flow cytometry analysis.
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Kang, M. H., van Lieshout, L. P., Xu, L., Domm, J. M., Vadivel, A., Renesme, L., Mühlfeld, C., Hurskainen, M., Mižíková, I., Pei, Y., van Vloten, J. P., Thomas, S. P., Milazzo, C., Cyr-Depauw, C., Whitsett, J. A., Nogee, L. M., Wootton, S. K., & Thébaud, B. (2020). A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency. Nature Communications, 11(1), 3929. https://doi.org/10.1038/s41467-020-17577-8 Cite
In vitro studies showed that low-dose bisphenol A promoted the proliferation of human prostate fibroblasts and epithelial cells, and significantly upregulated the expression of cyclooxygenase-2 (COX-2) and L-PGDS in the cells.
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Researchers showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.
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The authors discuss the important roles of mucins that lead to the lethality of pancreatic adenocarcinoma, particularly MUC1, MUC4, MUC5AC and MUC16 in disease progression, and present a comprehensive analysis of the clinical application of mucins and their promising roles in cancer treatment.
[Journal of Cellular and Molecular Medicine]
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Mucins in pancreatic cancer: A well‐established but promising family for diagnosis, prognosis and therapy - Wang - - Journal of Cellular and Molecular Medicine - Wiley Online Library. (n.d.). Retrieved August 4, 2020, from https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.15684 Cite
A 96-well microplate system was developed where primary human small airway epithelial cells were cultured at an air–liquid interface (ALI). After four weeks of ALI culture, a pseudostratified epithelium containing basal, club, goblet and ciliated cells was produced.
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Bluhmki, T., Bitzer, S., Gindele, J. A., Schruf, E., Kiechle, T., Webster, M., Schymeinsky, J., Ries, R., Gantner, F., Bischoff, D., Garnett, J., & Heilker, R. (2020). Development of a miniaturized 96-Transwell air–liquid interface human small airway epithelial model. Scientific Reports, 10(1), 13022. https://doi.org/10.1038/s41598-020-69948-2 Cite