Characterizing Cellular Heterogeneity in Fibrotic Hypersensitivity Pneumonitis by Single-Cell Transcriptional Analysis

Utilizing an integrated strategy based on scRNA-seq, scTCR-seq, and bulk RNA-seq analysis of fibrotic hypersensitivity pneumonitis profiles, the authors identified ten major cell types and 19 unique subtypes.
[Cell Death Discovery]
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Prostate Luminal Progenitor Cells: From Mouse to Human, from Health to Disease

The authors provide an overview of the intrinsic functional properties of luminal progenitor cells, and address their relevance in mouse and human prostate pathophysiology.
[Nature Reviews Urology]
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A Simple Method to Generate Human Airway Epithelial Organoids with Externally-Oriented Apical Membranes

Investigators described a simple method to generate organoid cultures using isolated human tracheobronchial epithelial cells grown in mixed matrix components and supplemented at day 14 with the Wnt pathway agonist R-spondin 2 and the bone morphogenic protein antagonist Noggin.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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A Medium Composition Containing Normal Resting Glucose That Supports Differentiation of Primary Human Airway Cells

Investigators expanded and differentiated human basal cells isolated from the nasal and conducting airway to a mature mucociliary epithelial cell layer at air–liquid interface using a medium formulation containing normal resting glucose levels.
[Scientific Reports]
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The HDAC2/SP1/miR-205 Feedback Loop Contributes to Tubular Epithelial Cell Extracellular Matrix Production in Diabetic Kidney Disease

The authors described a novel feedback loop composed of histone deacetylase 2 (HDAC2) and miR-205 that regulated ECM production in tubular epithelial cells in individuals with diabetic kidney disease.
[Clinical Science]
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Microbial Signals, MyD88, and Lymphotoxin Drive TNF-Independent Intestinal Epithelial Tissue Damage

Researchers showed that TNF-independent intestinal epithelial cells death after A20 and Abin-1 deletion was rescued by germ-free derivation or deletion of MyD88, while deletion of Trif provided only partial protection.
[Journal of Clinical Investigation]
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Characterization of the COPD Alveolar Niche Using Single-Cell RNA Sequencing

The authors analyzed single-cell RNA sequencing profiles of explanted lung tissue from subjects with advanced COPD or control lungs and identified a subpopulation of alveolar epithelial type II cells with transcriptional evidence for aberrant cellular metabolism and reduced cellular stress tolerance in COPD.
[Nature Communications]
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ArkBio Announces Completion of Patient Enrollment and Dosing in AIRFLO, a Phase III Registration Trial of Ziresovir for Treatment of Respiratory Syncytial Virus Infection

Ark Biopharmaceutical Co., Ltd. announced the completion of patient enrollment and dosing of ziresovir for the treatment of respiratory syncytial virus infection in a Phase III registration clinical trial.
[Ark Biopharmaceutical Co., Ltd.]
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SARS-CoV-2 Targets the Lysosome to Mediate Airway Inflammatory Cell Death

Emerging evidence suggests that SARS-CoV-2 could trigger pyroptosis, a form of inflammatory programmed cell death characterized by the activation of inflammasomes and caspase 1 and the formation of transmembrane pores by gasdermin D.
[Autophagy]
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TSLP Impairs Epidermal Barrier Integrity by Stimulating the Formation of Nuclear IL-33/Phosphorylated STAT3 Complex in Human Keratinocytes

Researchers stimulated post-confluent human keratinocytes and living skin equivalent with TSLP to investigate the role of nuclear IL-33 in TSLP-induced epidermal barrier defects.
[Journal of Investigative Dermatology]
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Oncogenic Potential of BEST4 in Colorectal Cancer via Activation of PI3K/Akt Signaling

BEST4 is a member of the bestrophin protein family that plays a critical role in human intestinal epithelial cells. Scientists investigated the role and clinical significance of BEST4 in CRC.
[Oncogene]
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