cardiomyocytes

[Cell Death Discovery] Septin4 enhanced the binding between hypoxia-inducible factor 1 alpha (HIF-1α) and the E3 ubiquitin ligase von Hippel-Lindau protein (VHL) to down-regulate HIF-1α. By reducing cardio-protective factor HIF-1α levels, Septin4 aggravated the hypoxia-induced cardiomyocytes apoptosis.

[Nature Communications] The authors used in situ cryo-electron tomography to unveil sarcomere contraction in frozen-hydrated neonatal rat cardiomyocytes.

[Scientific Reports] Scientists investigated the effects of mitoTEMPO, a mitochondria-targeted antioxidant, and resveratrol, a sirtuin activator, on nicotine-induced cardiac remodeling and dysfunction.

[Cell Death & Disease] Ischemia/reperfusion (IR) injury mice with myocardial overexpression GDF11 exhibited a significantly smaller myocardial infarct size, less cardiac remodeling and dysfunction, fewer apoptotic cardiomyocytes, higher telomerase activity, longer telomeres, and higher ATP generation than IR mice treated with an adenovirus carrying a negative control plasmid.

[NPJ Regenerative Medicine] Researchers demonstrated that cardiomyocyte proliferation greatly contributed to heart regeneration in adult Xenopus tropicalis upon apex resection.

[Science Translational Medicine] Researchers investigated an adeno-associated virus 9–based gene therapy to locally knock down the Hippo pathway gene Salvador in border zone cardiomyocytes in a pig model of ischemia/reperfusion-induced myocardial infarction.