cell proliferation

[npj Breast Cancer] The authors evaluated the transcriptome of an extended series of inflammatory breast cancer (IBC) preclinical models and performed a comparative analysis with patient samples to determine the extent to which the current models recapitulate the molecular characteristics of IBC observed clinically.

[Cell Death & Disease] Scientists found that NEK2 knockdown attenuated cell proliferation, migration, invasion, and tumorigenesis of glioblastoma (GBM) while NEK2 overexpression promoted the GBM progression.

[Science Signaling] Researchers reported the identification of a previously uncharacterized oncogenic signaling pathway in hepatocellular carcinoma that was mediated by the tyrosine kinase Yes.

[Oncogenesis] Researchers showed that the expression of EDDM3A was significantly upregulated in gastric cancer tissues and its upregulation correlates with poorer survival in patients with gastric cancer.

[Nature Nanotechnology] Researchers demonstrated that subcutaneous delivery via poly(ethylene glycol)-b-poly(propylene sulfide) polymersome nanocarriers significantly altered rapamycin’s cellular biodistribution to repurpose its mechanism of action for tolerance, instead of immunosuppression, and minimize side effects.

[Cell Reports] Investigators reported an epithelium-intrinsic requirement for Zeb1, a core transcriptional inducer of epithelial-to-mesenchymal transition, for mammary epithelial ductal side branching and for basal cell regenerative capacity.