cell proliferation

[Acta Biomaterialia] Decellularized ECM deposited by immortalized cells significantly influenced replicative senescent infrapatellar fat pad-derived stem cells in proliferation and differentiation preference, the effect of which was hinged on the approach of immortalization using either simian virus 40 large T antigen (SV40LT) or human telomerase reverse transcriptase (hTERT).

[Journal of Nanobiotechnology] Investigators evaluated the efficacy of hyaluronic acid (HA) functionalized collagen nanofibers in modulating the pro-healing phenotype expression of macrophages for urethral regeneration.

[Scientific Reports] Investigators reconstructed the metabolic pattern in progression of cancer to identify genetic changes specific in cancer cells. The prognostic model based on glycolysis genes showed high area under the curve in liver hepatocellular carcinoma.

[Journal of Experimental & Clinical Cancer Research] Investigators found that LNCAROD was significantly upregulated and predicted a poorer prognosis in hepatocellular carcinoma (HCC) patients. LNCAROD significantly promoted HCC cell proliferation, migration, invasion, and chemoresistance both in vitro and in vivo.

[Journal of Experimental & Clinical Cancer Research] The authors identified the novel transcriptional factor ZNF507 as a key mediator in the progression of prostate cancer to an aggressive state.

[Cancer Gene Therapy] Researchers found that the RNA-binding protein LIN28B, a known regulator of microRNA biogenesis, stem cell maintenance, and oncogenesis, was expressed in a subpopulation of cholangiocarcinoma patients.