cell transplantation

[American Society for Transplantation and Cellular Therapy] Researchers described an umbilical cord blood transplants performed after graft failure following a previous hematopoietic stem cell transplantation.

[Pharmacogenomics Journal] Scientists explored 51 variants within 17 DNA-repair genes for their association with acute graft versus host disease grades two–four in 60 pediatric patients.

[International Journal of Hematology] The authors evaluated the effect of reducing the melphalan dose and retrospectively compared transplant outcomes in 156 patients who received FB2 (n = 103) or FM80 (n = 53) at the center (median age: 63 years; range 27–72 years).

[Leukemia & Lymphoma] Researchers investigated the efficiency and prognostic role of cytoplasmic CD79a antibody-gated multicolor flow cytometry in minimal residual disease detection in patients with B-ALL who received CD19-targeted chimeric antigen receptor (CAR) T-cell therapy bridging to allogeneic hematopoietic stem cell transplantation.

[Journal of Clinical Immunology] The authors found that donor engraftment in the myeloid compartment was significantly diminished in unconditioned procedures, which typically use a HLA-matched sibling donor or family donor.

[Bone Marrow Transplantation] Investigators provide an overview of the cellular therapies available for the management of systemic sclerosis, including systemically injected therapies and locally administered regenerative cell therapies.