GvHD-Free, Relapse-Free Survival Provides Novel Clues for Optimizing Allogeneic-HSCT for Adult T-Cell Leukemia/Lymphoma

The authors performed a nationwide retrospective study of graft-versus-host disease (GvHD)-free, relapse-free survival of patients with allogeneic hematopoietic stem cell transplantation (HSCT)-treated adult T-cell leukemia/lymphoma.
[Bone Marrow Transplantation]
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Regenerative Effects of Human Chondrocyte Sheets in a Xenogeneic Transplantation Model Using Immune‐Deficient Rats

Researchers investigated the regenerative effects of human chondrocyte sheets on articular cartilage in a xenogeneic transplantation model using immune‐deficient rats.
[Journal of Tissue Engineering and Regenerative Medicine]
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Which Lower Risk Myelodysplastic Syndromes Should Be Treated with Allogeneic Hematopoietic Stem Cell Transplantation?

The authors review prognostic factors in lower risk MDS, delineating patients with relatively poor risk who may potentially benefit from hematopoietic stem cell transplantation during the disease course.
[Leukemia]
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Phase I Dose Escalation Study of Naive T-Cell Depleted Donor Lymphocyte Infusion following Allogeneic Stem Cell Transplantation

In this Phase I dose escalation study, the authors assessed the safety of a donor lymphocyte infusion that was depleted of CD45RA+ naive T cells.
[Bone Marrow Transplantation]
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Endothelial Progenitor Cell Transplantation Restores Vascular Injury in Mice after Whole-brain Irradiation

Flow cytometry demonstrated that irradiation led to a significant reduction in the peripheral blood endothelial progenitor cell (EPC) count; however, EPC transplantation led to a significant increase in the circulating EPCs.
[Brain Research]
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Long-Term Outcomes of Cultivated Cell Sheet Transplantation for Treating Total Limbal Stem Cell Deficiency

This study was conducted to determine the long-term outcomes of cultivated cell sheet transplantation, and to clarify risk factors that affected the outcomes.
[Ocular Surface]
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Defining an Optimal Dual-Targeted CAR T-Cell Therapy Approach Simultaneously Targeting BCMA and GPRC5D to Prevent BCMA Escape-Driven Relapse in Multiple Myeloma

Scientists demonstrated that simultaneous targeting of an additional antigen—here, G protein-coupled receptor class-C group-5 member-D (GPRC5D)—can prevent B-cell maturation antigen escape–mediated relapse in a model of multiple myeloma. To identify an optimal approach, they compared subtherapeutic doses of different forms of dual-targeted cellular therapy.
[Blood Cancer Discovery]
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Bone Marrow-Derived Mesenchymal Stem Cells Improve Cognitive Impairment in an Alzheimer’s Disease Model by Increasing the Expression of MicroRNA-146a in Hippocampus

Investigators showed that intracerebroventricularly injected bone marrow mesenchymal stem cells improved cognitive impairment in Alzheimer’s disease model mice by ameliorating astrocytic inflammation as well as synaptogenesis.
[Scientific Reports]
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Mybl2 Rejuvenates Heart Explant‐Derived Cells from Aged Donors after Myocardial Infarction

In vivo, scientists observed an increase in cell retention and vasculogenesis after treatment with Mybl2‐over‐expressing explant‐derived cells which improved heart function in infarcted recipient hearts.
[Aging Cell]
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Oncolytic Virus-Derived Type I Interferon Restricts CAR T Cell Therapy

Investigators tested whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells.
[Nature Communications]
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Factors That Predict Delayed Platelet Recovery after Autologous Stem Cell Transplantation for Lymphoma or Myeloma

Platelet recovery following autologous stem cell transplantation (ASCT) was affected by insufficient hematopoietic recovery at stem cell harvest, a need for repeated apheresis, and high fever early after ASCT, particularly when the amount of infused stem cells was insufficient.
[Annals of Hematology]
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