cell viability assay

[Scientific Reports] Cell viability assay revealed that apiin, rhoifolin, and vitexin could inhibit proliferation of PANC-1 and ASPC-1, with rhoifolin showing the maximum inhibitory effect.

[Journal of Neurovirology] The authors characterised the progression of chikungunya virus (CHIKV) infection in the human microglial cell line CHME-3. The susceptibility of these cells to CHIKV and the viral replication kinetics were assessed during the early and late phases of infection.

[Experimental Hematology & Oncology] In vitro mammary spheroid formation, flow cytometry assay on CD24−/CD44+ sub-population, ALDH activity detection, cell viability assay and western blot analysis, and in vivo tumor-initiating analysis were performed to examine the effects of Tanshinone IIA on the stemness of breast cancer cells.

[Biochemical and Biophysical Research Communications] Investigators used prostate cancer cell line PC3 and its paclitaxel-resistant counterpart PC3-TxR as the cell model and suggested that lovastatin (LV) might increase the sensitivity of resistant prostate cancer cells to paclitaxel through inhibition of CYP2C8.

[Journal of Gene Medicine] Expression of circular RNA derived from dipeptidyl peptidase 4 (circDPP4) was upregulated in prostate cancer (PC) tumors from 60 patients and PC cell lines, and higher circDPP4 might predict poor overall survival. Decreasing circDPP4 suppresses cell proliferation, colony formation, migration/invasion, and 50% inhibitory concentration of docetaxel in PC cells.

[Cell Death Discovery] Researchers explored the potential functions of hypoxia-induced upregulation of Fascin-1 in liver cancer and found that Fascin-1 was upregulated by hypoxia in liver cancer cell lines, elevated in liver cancer patients and correlated with larger tumor size, lymph node metastasis, distant metastasis, and shorter overall survival.