Complement Activation by an Angiogenic Imbalance Leads to Systemic Vascular Endothelial Dysfunction: A New Proposal for the Pathophysiology of Preeclampsia

Scientists evaluated whether angiogenic imbalance affected the expression and secretion of inhibitory complement factor H in endothelial cells, resulting in complement activation and systemic vascular endothelial dysfunction.
[Journal of Reproductive Immunology]
Matsuyama, T., Tomimatsu, T., Mimura, K., Yagi, K., Kawanishi, Y., Kakigano, A., Nakamura, H., Endo, M., & Kimura, T. (2021). Complement activation by an angiogenic imbalance leads to systemic vascular endothelial dysfunction: A new proposal for the pathophysiology of preeclampsia. Journal of Reproductive Immunology, 145, 103322. https://doi.org/10.1016/j.jri.2021.103322 Cite
Abstract
Bookmark

No account yet? Register

0
Share

1 E-Cadherin Knockdown Induces Cancer Stem Cell-Like Phenotype and Drug Resistance

CSC phenotype cells were isolated and the expression of stem cell marker and epithelial-mesenchymal transition associated gene was confirmed by various assays.
[Biochemistry and Cell Biology]
Sharma, D. A., Kaur, D. H., De, M. R., Srinivasan, P. R., Pal, D. A., & Bhattacharyya, P. S. B. (2021, March 6). 1 E-Cadherin knockdown induces cancer stem cell-like phenotype and drug resistance [Research-article]. Https://Doi.Org/10.1139/Bcb-2020-0592. https://doi.org/10.1139/bcb-2020-0592 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Cytotoxicity and Apoptosis Effects of Curcumin Analogue (2E,6E)-2,6-Bis(2,3-Dimethoxybenzylidine) Cyclohexanone (DMCH) on Human Colon Cancer Cells HT29 and SW620 In Vitro

Researchers retrospectively evaluated the outcomes of single-unit cord blood transplantation in 1577 patients aged ≥60 years with acute myeloid leukemia in Japan between 2002 and 2017.
[Molecules]
Rahim, N. F. C., Hussin, Y., Aziz, M. N. M., Mohamad, N. E., Yeap, S. K., Masarudin, M. J., Abdullah, R., Akhtar, M. N., & Alitheen, N. B. (2021). Cytotoxicity and Apoptosis Effects of Curcumin Analogue (2E,6E)-2,6-Bis(2,3-Dimethoxybenzylidine) Cyclohexanone (DMCH) on Human Colon Cancer Cells HT29 and SW620 In Vitro. Molecules, 26(5), 1261. https://doi.org/10.3390/molecules26051261 Cite
Full Article
Bookmark

No account yet? Register

0
Share

NFAT2 Overexpression Suppresses the Malignancy of Hepatocellular Carcinoma through Inducing Egr2 Expression

The pcDNA3.1-NFAT2 plasmid was transfected into HepG2 cells to construct NFAT2 overexpressed HepG2 cells. Then, the chemical count kit-8 cell viability assay, Annexin V-FITC apoptosis detection, EdU labeling proliferation detection, transwell and wound healing experiments were performed.
[BMC Cancer]
Wang, J., Zhang, Y., Liu, L., Cui, Z., Shi, R., Hou, J., Liu, Z., Yang, L., Wang, L., & Li, Y. (2020). NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression. BMC Cancer, 20(1), 966. https://doi.org/10.1186/s12885-020-07474-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Combination Therapy of Cold Atmospheric Plasma (CAP) With Temozolomide in the Treatment of U87MG Glioblastoma Cells

Investigators explored whether CAP, an ionized gas produced in laboratory settings and that operates at near room temperature, can enhance Temozolomide cytotoxicity on a glioblastoma cell line.
[Scientific Reports]
Raghuraman, S., Xie, J. Y., Giacobassi, M. J., Tun, J. O., Chase, K., Lu, D., Teichert, R. W., Porreca, F., & Olivera, B. M. (2020). Chronicling changes in the somatosensory neurons after peripheral nerve injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1922618117 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Zingerone Suppresses Cell Proliferation via Inducing Cellular Apoptosis and Inhibition of the PI3K/AKT/mTOR Signaling Pathway in Human Prostate Cancer PC-3 Cells

Scientists evaluated the efficacy of zingerone at different doses on the prostate cancer cell line regarding apoptosis, upstream signing molecules such as Akt/mTOR, and migration metastasis.
[Journal of Biochemical and Molecular Toxicology]
Zingerone suppresses cell proliferation via inducing cellular apoptosis and inhibition of the PI3K/AKT/mTOR signaling pathway in human prostate cancer PC‐3 cells - Qian - - Journal of Biochemical and Molecular Toxicology - Wiley Online Library. (n.d.). Retrieved September 10, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22611 Cite
Abstract
Bookmark

No account yet? Register

0
Share

hADSCs Derived Extracellular Vesicles Inhibit NLRP3inflammasome Activation and Dry Eye

Investigators addressed the therapeutic efficacy of human adipose tissue stem cells derived extracellular vesicles in a mouse model of dry eye disease and to investigate the underlying mechanisms involved.
[Scientific Reports]
Yu, C., Chen, P., Xu, J., Liu, Y., Li, H., Wang, L., & Di, G. (2020). hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye. Scientific Reports, 10(1), 14521. https://doi.org/10.1038/s41598-020-71337-8 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share