Scientists evaluated whether angiogenic imbalance affected the expression and secretion of inhibitory complement factor H in endothelial cells, resulting in complement activation and systemic vascular endothelial dysfunction.
Matsuyama, T., Tomimatsu, T., Mimura, K., Yagi, K., Kawanishi, Y., Kakigano, A., Nakamura, H., Endo, M., & Kimura, T. (2021). Complement activation by an angiogenic imbalance leads to systemic vascular endothelial dysfunction: A new proposal for the pathophysiology of preeclampsia. Journal of Reproductive Immunology, 145, 103322. https://doi.org/10.1016/j.jri.2021.103322Cite
Sharma, D. A., Kaur, D. H., De, M. R., Srinivasan, P. R., Pal, D. A., & Bhattacharyya, P. S. B. (2021, March 6). 1 E-Cadherin knockdown induces cancer stem cell-like phenotype and drug resistance [Research-article]. Https://Doi.Org/10.1139/Bcb-2020-0592. https://doi.org/10.1139/bcb-2020-0592 Cite
Rahim, N. F. C., Hussin, Y., Aziz, M. N. M., Mohamad, N. E., Yeap, S. K., Masarudin, M. J., Abdullah, R., Akhtar, M. N., & Alitheen, N. B. (2021). Cytotoxicity and Apoptosis Effects of Curcumin Analogue (2E,6E)-2,6-Bis(2,3-Dimethoxybenzylidine) Cyclohexanone (DMCH) on Human Colon Cancer Cells HT29 and SW620 In Vitro. Molecules, 26(5), 1261. https://doi.org/10.3390/molecules26051261Cite
The pcDNA3.1-NFAT2 plasmid was transfected into HepG2 cells to construct NFAT2 overexpressed HepG2 cells. Then, the chemical count kit-8 cell viability assay, Annexin V-FITC apoptosis detection, EdU labeling proliferation detection, transwell and wound healing experiments were performed.
Raghuraman, S., Xie, J. Y., Giacobassi, M. J., Tun, J. O., Chase, K., Lu, D., Teichert, R. W., Porreca, F., & Olivera, B. M. (2020). Chronicling changes in the somatosensory neurons after peripheral nerve injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1922618117Cite
Zingerone suppresses cell proliferation via inducing cellular apoptosis and inhibition of the PI3K/AKT/mTOR signaling pathway in human prostate cancer PC‐3 cells - Qian - - Journal of Biochemical and Molecular Toxicology - Wiley Online Library. (n.d.). Retrieved September 10, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22611Cite
Investigators addressed the therapeutic efficacy of human adipose tissue stem cells derived extracellular vesicles in a mouse model of dry eye disease and to investigate the underlying mechanisms involved.