Hu, A., Hong, F., Li, D., Xie, Q., Chen, K., Zhu, L., & He, H. (2021). KDM3B-ETF1 fusion gene downregulates LMO2 via the WNT/β-catenin signaling pathway, promoting metastasis of invasive ductal carcinoma. Cancer Gene Therapy, 1–10. https://doi.org/10.1038/s41417-021-00301-zCite
Researchers subjected low-glycolytic breast cancer cells to different microenvironmental selection pressures using combinations of hypoxia, acidosis, low glucose, and starvation for many months and isolated single clones for metabolic and transcriptomic profiling.
[Proceedings of the National Academy of Sciences of the United States of America]
Human breast cancer cell culture models revealed that siRNA-mediated silencing of transmembrane protease, serine 13 (TMPRSS13) expression decreased proliferation, induced apoptosis, and attenuated invasion.
Murray, A. S., Hyland, T. E., Sala-Hamrick, K. E., Mackinder, J. R., Martin, C. E., Tanabe, L. M., Varela, F. A., & List, K. (2020). The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy. Oncogene, 1–16. https://doi.org/10.1038/s41388-020-01436-3Cite