embryonic stem cells

[Molecular Therapy-Methods & Clinical Development] Investigators found that the editing efficiency of cytosine base editor was significantly lower than that of adenine base editor in human ESCs, which were associated with high expression of DNA glycosylases, the key component of the base excision repair pathway.

[Nature Communications] Scientists explored the roles of two distinct Polycomb Repressive Complex 2 (PRC2) complexes in lineage specification and commitment, using single-cell transcriptomics and mouse embryoid bodies derived from Mtf2 and Jarid2 null ESCs.

[AgeX Therapeutics, Inc. (BusinessWire, Inc.)] AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc. has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.

[Stem Cell Research & Therapy] The authors outline current approaches aiming to improve the beneficial outcomes of cell therapy to better grasp clinical cell transformation.

[Cell Death & Disease] Researchers showed that nicotinamide played multiplex roles in mesoderm differentiation of human ESCs. Nicotinamide promoted cardiomyocyte fate from mesoderm progenitor cells, and suppressed the emergence of other cell types.

[Journal of Molecular and Cellular Cardiology] Investigators demonstrated marker expression and matrix competency of cardiac fibroblasts developed through a developmentally conserved epicardial pathway as shown next to primary human cardiac fibroblasts.