embryonic stem cells

[Nucleic Acids Research] Researchers reported a transcription initiation-centric, in-depth characterization of the transposon-derived regulatory landscape of mESCs.

[EMBO Reports] Investigators showed that heterochromatin protein 1 (HP1) interaction-defective mutants of H3K9 MTs, Suv39h1 and Setdb1, underwent protein degradation. They further established mESC lines lacking all three HP1 paralogs.

[Stem Cell Reviews and Reports] The authors highlight the recent progress on the role of endoplasmic reticulum and mitochondria in maintaining PSCs redox status, focusing on metabolism.

[Leukemia] The authors investigated the use of human iPSCs and ESCs to develop a source of endothelial colony-forming cells-like cells for vascular repair.

[Nature Communications] To dissect the dynamic regulation of Runx1 in hematopoietic development, researchers analyzed its 3D chromatin conformation in mouse ESC differentiation cultures.

[Nature Protocols] Investigators described how to grow human PSCs such as human induced pluripotent and ESCs in a physically confined area and efficiently differentiate them into a highly enriched population of healthy and functional midbrain dopamine progenitors and midbrain dopamine neurons.