embryonic stem cells

[Communications Biology] Investigators demonstrated that the replacement of meiotic spindles in mature metaphases II arrested oocytes with nuclei of somatic cells in the G0/G1 stage of cell cycle resulted in the formation of de novo spindles consisting of somatic homologous chromosomes comprising of single chromatids.

[Scientific Reports] Scientists developed a mass spectrometry-based proof-of-concept to assess a histone code screening assay capable of simultaneously detecting multiple hPTM-changes in human ESCs.

[Nature Communications] The authors developed an adenine base editor-based strategy to systematically identify functional m6A sites that controlled lineage decisions of human #ESCs.

[Stem Cell Reports] Investigators interrogated the contribution of the Hippo signaling effector YAP1 to the formation of the three germ layers by analyzing human ESC-derived 2D-micropatterned gastruloids.

[Nature Communications] The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.

[Stem Cell Reports] Scientists showed that PIKfyve inhibitors could selectively eliminate pluripotent embryonal carcinoma cells, ESCs, and iPSCs under conditions where differentiated cells remained viable.