endothelial cells

[Scientific Reports] The authors examined 42 renal biopsy samples representing endocapillary proliferative lesions from post-streptococcal acute glomerulonephritis, Henoch–Schönlein purpura nephritis, and lupus nephritis

[Scientific Reports] Investigators proposed that replacing donor endothelial cells alone, while keeping the rest of the organ viable and functional, is more technically feasible, and may offer a significant shortcut in the efforts to engineer transplantable organs.

[EMBO Journal] Using PRKCB2 as bait, scientists identified functional ortholog of veal2 in humans from HUVECs and named it as VEAL2.

[Life Sciences] The authors summarize the current knowledge on the cardiac signaling pathways modulated by two antineoplastic drugs highly used in the management of breast cancer, not only focusing on cardiomyocytes but also to broaden the knowledge of the potential impact on other cells found in the heart.

[Nature Communications] Using single-cell RNA sequencing, scientists delineated the transcriptional heterogeneity of human bone marrow endothelium, showing increased expression of inflammatory genes, including IL1B and MYC, in ischemic heart failure.

[Cell Death & Disease] Scientists showed that TNF-α strongly induced human endothelial cells to undergo Endothelial–mesenchymal transition. They also showed that TNF-α-induced EndMT was reversible. Furthermore, TNF-α treatment of orthotopic mice resulted in an important increase in the stroma, including cancer-associated fibroblasts.