extracellular matrix

[Scientific Reports] Scientists performed co-culture experiments with tumor cells and fibroblasts embedded in 3D collagen I matrices and investigated the impact of fibroblasts on the migratory behavior of neighboring tumor cells and on the evolution of the surrounding ECM.

[Scientific Reports] Scientists performed a randomized, controlled study to investigate the effects of mesenchymal stem cell injection for treating partial tears in the supraspinatus tendon.

[NPJ Regenerative Medicine] Researchers developed an “off-the-shelf” adipose ECM biomaterial from allograft human tissue, applying physical and chemical processing methods to remove lipids and create an injectable matrix that mimicked the properties of lipoaspirate.

[Journal of Cell Science] The authors highlight the role of the Golgi in the formation of an adaptable, healthy matrix, with a focus on proteoglycan and procollagen secretion as example cargoes.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Investigators revealed a continuous signaling pathway, MAPK p38-Ulk1 phosphorylation-Ulk1/Atg13 disruption, which inhibited autophagy and induced IL-1β expression in hepatic stellate cells.

[Artificial Organs] Human placenta was decellularized by four protocols and decellularization efficacy was compared by hematoxylin and eosin, 4′,6-diamidino-2-phenylindole staining, and DNA measurement.