extracellular matrix

[Cell Reports] Investigators confirmed that CXCL4 directly induced myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition.

[Bone Research] Researchers utilized a bone morphogenetic protein-2-loaded scaffold to create periosteum-like tissue in vivo, mimicking the mesenchymal condensation during native long bone development.

[Pharmacological Research] Researchers found that the level of lactate dehydrogenase A (LDHA) was significantly elevated in aortic dissection patients and the mouse model established by BAPN combined with Ang II.

[Nature Reviews Cardiology] The authors summarize the current evidence on the role of TGFβ signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discuss challenges and opportunities for therapeutic translation.

[Endocrine Journal] Knockdown of potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) suppressed proliferation, ECM accumulation, inflammation, and oxidative stress in high glucose (HG)-cultured human glomerular mesangial cells in vitro.

[Acta Biomaterialia] The authors bioengineered a physiologically relevant 3D scaffold by integrating brain-like extracellular matrix components and chemical cues.