Synergistic Hyperactivation of Both mTORC1 and mTORC2 Underlies the Neural Abnormalities of PTEN-Deficient Human Neurons and Cortical Organoids

Investigators showed that pluripotent stem cell-derived phosphatase and tensin homolog (PTEN) mutant human neurons, neural precursors, and cortical organoids recapitulated disease-relevant phenotypes, including hypertrophy, electrical hyperactivity, enhanced proliferation, and structural overgrowth.