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fibroblasts

BAG3 Induces Fibroblasts to Release Key Cytokines Involved in Pancreatic Cell Migration

[Journal of Cellular Biochemistry] Researchers examined the role of Bcl2-associated athanogene (BAG3) to activate human fibroblasts in releasing cytokines capable of supporting tumor progression.

Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth

[Cancer Stem Cell News, Intestinal Cell News] The authors observed elevated expression of full-length ECT2 protein in preneoplastic colon adenomas, driven by increased ECT2 mRNA abundance and associated with APC tumor suppressor loss.

Direct Conversion of Cell Fate and Induced Endothelial Cells

[Circulation Journal] Researchers suggest that careful assessment of the status of converted cells using genetic and epigenetic profiling, various functional assays, and the use of multiple readouts is essential to determine successful conversion.

FOXM1 Accelerates Wound Healing in Diabetic Foot Ulcer by Inducing M2 Macrophage Polarization through a Mechanism Involving SEMA3C/NRP2/Hedgehog Signaling

[Diabetes Research and Clinical Practice] Scientists illustrated the molecular mechanisms by which Forkhead box M1 (FOXM1) enhanced M2 polarization and wound healing of diabetic foot ulcer.

Tpl2 Contributes to IL-1β-Induced IL-8 Expression via ERK1/2 Activation in Canine Dermal Fibroblasts

[PLoS One] Investigators established a model for interleukin 1β (IL-1β)-induced dermatitis and investigated mitogen-activated protein kinase signaling pathways in IL-1β-induced interleukin 8 (IL-8) expression.

High Salt Diet Impairs Dermal Tissue Remodeling in a Mouse Model of IMQ Induced Dermatitis

[PLoS One] Researchers studied the effect of dietary salt loading on inflammatory process and related extracellular matrix remodeling in the skin. The effect of high salt concentration on dermal fibroblasts and peripheral blood mononuclear cells was investigated in vitro.

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