ATF4 Links ER Stress With Reticulophagy in Glioblastoma Cells

The authors explored the autophagy-inducing mechanisms that underlie the autophagic cell death-triggering compound loperamide in glioblastoma cells.
[Journal of Autophagy]
Zielke, S., Kardo, S., Zein, L., Mari, M., Covarrubias-Pinto, A., Kinzler, M. N., Meyer, N., Stolz, A., Fulda, S., Reggiori, F., Kögel, D., & Wijk, S. J. L. van. (2020). ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy, 0(0), 1–17. https://doi.org/10.1080/15548627.2020.1827780 Cite
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Reduced EGFR and Increased miR-221 Is Associated with Increased Resistance to Temozolomide and Radiotherapy in Glioblastoma

Researchers explored the underlying mechanisms behind treatment resistance and the lack of success with anti-EGFR therapy in the clinic. After generating a number of treatment resistant Glioblastoma cell lines they observed that resistant cell lines lacked EGFR activation and expression.
[Scientific Reports]
Areeb, Z., Stuart, S. F., West, A. J., Gomez, J., Nguyen, H. P. T., Paradiso, L., Zulkifli, A., Jones, J., Kaye, A. H., Morokoff, A. P., & Luwor, R. B. (2020). Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma. Scientific Reports, 10(1), 17768. https://doi.org/10.1038/s41598-020-74746-x Cite
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Combination Therapy of Cold Atmospheric Plasma (CAP) With Temozolomide in the Treatment of U87MG Glioblastoma Cells

Investigators explored whether CAP, an ionized gas produced in laboratory settings and that operates at near room temperature, can enhance Temozolomide cytotoxicity on a glioblastoma cell line.
[Scientific Reports]
Raghuraman, S., Xie, J. Y., Giacobassi, M. J., Tun, J. O., Chase, K., Lu, D., Teichert, R. W., Porreca, F., & Olivera, B. M. (2020). Chronicling changes in the somatosensory neurons after peripheral nerve injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1922618117 Cite
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Quantitative In Vivo Bioluminescence Imaging of Orthotopic Patient-Derived Glioblastoma Xenografts

Scientists showed that stable expression of near-infrared fluorescent protein in patient-derived glioblastoma cells enabled rapid, direct non-invasive monitoring of tumor development without compromising tumor stemness or tumorigenicity.
[Scientific Reports]
Koessinger, A. L., Koessinger, D., Stevenson, K., Cloix, C., Mitchell, L., Nixon, C., Gomez-Roman, N., Chalmers, A. J., Norman, J. C., & Tait, S. W. G. (2020). Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Scientific Reports, 10(1), 15361. https://doi.org/10.1038/s41598-020-72322-x Cite
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Inhibition of Purinergic P2X Receptor 7 (P2X7R) Decreases Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Expression in U251 Glioblastoma Cells

Researchers investigated the potential mechanism linking P2X7R and GM-CSF in the U251 glioblastoma cell line and the therapeutic potential of P2X7R antagonism in this setting.
[Scientific Reports]
Drill, M., Powell, K. L., Kan, L. K., Jones, N. C., O’Brien, T. J., Hamilton, J. A., & Monif, M. (2020). Inhibition of purinergic P2X receptor 7 (P2X7R) decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells. Scientific Reports, 10(1), 14844. https://doi.org/10.1038/s41598-020-71887-x Cite
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TRPV4 Activates the Cdc42/N-Wasp Pathway to Promote Glioblastoma Invasion by Altering Cellular Protrusions

TRPV4 strongly colocalized and interacted with skeletal protein-F-actin at cellular protrusions, and TRPV4 regulated the formation of invadopodia and filopodia in glioblastoma cells.
[Scientific Reports]
Yang, W., Wu, P., Ma, J., Liao, M., Xu, L., & Yi, L. (2020). TRPV4 activates the Cdc42/N-wasp pathway to promote glioblastoma invasion by altering cellular protrusions. Scientific Reports, 10(1), 14151. https://doi.org/10.1038/s41598-020-70822-4 Cite
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TGF-β1 Modulates Temozolomide Resistance in Glioblastoma via Altered microRNA Processing and Elevated MGMT

TGF-β1 treatment reduced cellular methylguanine DNA methyltransferase levels through suppressing the expression of miR-198. TGF-β1 upregulation did not affect KSRP expression in glioma cells.
[Neuro-Oncology]
Nie, E., Jin, X., Miao, F., Yu, T., Zhi, T., Shi, Z., Wang, Y., Zhang, J., Xie, M., & You, Y. (n.d.). TGF-β1 modulates temozolomide resistance in glioblastoma via altered microRNA processing and elevated MGMT. Neuro-Oncology. https://doi.org/10.1093/neuonc/noaa198 Cite
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Flavagline Synthetic Derivative Induces Senescence in Glioblastoma Cancer Cells without Being Toxic to Healthy Astrocytes

Investigators explored the effect of FL3 in glioblastoma cells under normoxia and hypoxia conditions. They indicated that this synthetic flavagline inhibits cell proliferation and induced senescence in glioblastoma cells cultured under both conditions.
[Scientific Reports]
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Doxorubicin-Loaded Iron Oxide Nanoparticles for Glioblastoma Therapy: A Combinational Approach for Enhanced Delivery of Nanoparticles

The doxorubicin (DOX) loaded ethylenediamine triacetic acid-iron oxide nanoparticles released DOX within four days with the capability of an accelerated release in acidic microenvironments.
[Scientific Reports]
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Microglia Promote Glioblastoma via mTOR-Mediated Immunosuppression of the Tumor Microenvironment

Investigators showed that glioblastoma (GBM)‐initiating cells induced mTOR signaling in the microglia but not bone marrow‐derived macrophages in both in vitro and in vivo GBM mouse models.
[Embo Journal]
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MicroRNA-128-3p Enhances the Chemosensitivity of Temozolomide in Glioblastoma by Targeting c-Met and EMT

The effects of miR-128-3p and temozolomide (TMZ) on the proliferation of glioblastoma cells were investigated by cell counting kit-8. Transwell and intracerebral invasion assays were applied to determine the effects of the combination of miR-128-3p and TMZ on the invasion and migration of glioblastoma in vitro and in vivo.
[Scientific Reports]
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