Using glioblastoma patient-derived stem cells, researchers identified and characterized a subset of Gal-3high glioblastoma tumors mainly within the mesenchymal subtype that are addicted to Gal-3-mediated macropinocytosis.
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To investigate whether H3K27M was associated with distinct chromatin structure that altered transcription regulation, investigators generated the first high-resolution genome structure maps of pediatric high-grade gliomas cell lines and tumor tissue.
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Researchers identified a Stat3/HIF-1α-mediated axis, through which IL-6 executed an anti-tumor role to induce CD40 expression in Mϕs.
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Yang, F., He, Z., Duan, H., Zhang, D., Li, J., Yang, H., Dorsey, J. F., Zou, W., Ali Nabavizadeh, S., Bagley, S. J., Abdullah, K., Brem, S., Zhang, L., Xu, X., Byrne, K. T., Vonderheide, R. H., Gong, Y., & Fan, Y. (2021). Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nature Communications, 12(1), 3424. https://doi.org/10.1038/s41467-021-23832-3 Cite
Investigators suggested that combined treatment with the DRD2/3 antagonist ONC201 and radiation improves the efficacy of radiation against glioblastoma (GBM) in vitro and in vivo through suppression of glioma-initiating cells without increasing toxicity in mouse models of GBM.
[Radiotherapy and Oncology]
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Scientists dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.
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Hara, T., Chanoch-Myers, R., Mathewson, N. D., Myskiw, C., Atta, L., Bussema, L., Eichhorn, S. W., Greenwald, A. C., Kinker, G. S., Rodman, C., Castro, L. N. G., Wakimoto, H., Rozenblatt-Rosen, O., Zhuang, X., Fan, J., Hunter, T., Verma, I. M., Wucherpfennig, K. W., Regev, A., … Tirosh, I. (2021). Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2021.05.002 Cite
Investigators interrogated gene expression in separate microenvironments of glioblastoma organoid models that mimicked the transition between nutrient-rich and nutrient-poor pseudopalisading/perinecrotic tumor zones using spatial-capture RNA-sequencing.
[Acta Neuropathologica Communications]
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Shakya, S., Gromovsky, A. D., Hale, J. S., Knudsen, A. M., Prager, B., Wallace, L. C., Penalva, L. O. F., Brown, H. A., Kristensen, B. W., Rich, J. N., Lathia, J. D., Brown, J. M., & Hubert, C. G. (2021). Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches. Acta Neuropathologica Communications, 9(1), 101. https://doi.org/10.1186/s40478-021-01205-7 Cite
Scientists generated a herpes simplex 1-based oncolytic viruses expressing human IL-15/IL-15Rα sushi domain fusion protein, as well as off-the-shelf EGFR-CAR NK cells, and studied their monotherapy and combination efficacy in vitro and in multiple glioblastoma mouse models.
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Scientists proposed that IL-1β influences human umbilical cord Wharton’s jelly derived mesenchymal stem cells migration involving matrix metalloproteinase-3.
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The safety and feasibility of using bone marrow–derived MSCs in combination with prodrug for treatment of patients with primary and secondary glioblastoma multiform was assessed.
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Researchers examined CD97 function in primary patient-derived glioma stem cells obtained from five glioblastoma tumors, belonging to three major genetic subtypes.
[Journal of Neuro-Oncology]
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Investigators present SFRP2 as a SOX2-antagonist with the capacity to induce a mesenchymal subtype transition in glioma cells located in vascular tumor areas, highlighting its role in glioblastoma tumor evolution and intratumoral heterogeneity.
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