Tunneling Nanotubes Mediate Adaptation of Glioblastoma Cells to Temozolomide and Ionizing Radiation Treatment

The authors showed that heterogeneous glioblastoma cells express TNTs upon oxidative stress and temozolomide/ionizing radiation treatment.
[iScience]
Valdebenito, S., Audia, A., Bhat, K. P. L., Okafo, G., & Eugenin, E. A. (2020). Tunneling nanotubes mediate adaptation of Glioblastoma Cells to temozolomide and ionizing radiation treatment. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101450 Cite
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Flavagline Synthetic Derivative Induces Senescence in Glioblastoma Cancer Cells without Being Toxic to Healthy Astrocytes

Investigators explored the effect of FL3 in glioblastoma cells under normoxia and hypoxia conditions. They indicated that this synthetic flavagline inhibits cell proliferation and induced senescence in glioblastoma cells cultured under both conditions.
[Scientific Reports]
Harmouch, E., Seitlinger, J., Chaddad, H., Ubeaud-Sequier, G., Barths, J., Saidu, S., Désaubry, L., Grandemange, S., Massfelder, T., Fuhrmann, G., Fioretti, F., Dontenwill, M., Benkirane-Jessel, N., & Idoux-Gillet, Y. (2020). Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes. Scientific Reports, 10(1), 13750. https://doi.org/10.1038/s41598-020-70820-6 Cite
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EGFR/FOXO3a/BIM Signaling Pathway Determines Chemosensitivity of BMP4-Differentiated Glioma Stem Cells to Temozolomide

Scientists examined whether epidermal growth factor receptor (EGFR) signaling affects bone morphogenic protein 4-induced differentiation of glioma stem cells and their response to the alkylating drug temozolomide.
[Experimental and Molecular Medicine]
Ciechomska, I. A., Gielniewski, B., Wojtas, B., Kaminska, B., & Mieczkowski, J. (2020). EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide. Experimental & Molecular Medicine, 1–15. https://doi.org/10.1038/s12276-020-0479-9 Cite
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Purine Metabolism Regulates DNA Repair and Therapy Resistance in Glioblastoma

By correlating intracellular metabolite levels with radiation resistance across dozens of genomically-distinct models of glioblastoma, researchers find that purine metabolites, especially guanylates, strongly correlate with radiation resistance.
[Nature Communications]
Zhou, W., Yao, Y., Scott, A. J., Wilder-Romans, K., Dresser, J. J., Werner, C. K., Sun, H., Pratt, D., Sajjakulnukit, P., Zhao, S. G., Davis, M., Nelson, B. S., Halbrook, C. J., Zhang, L., Gatto, F., Umemura, Y., Walker, A. K., Kachman, M., Sarkaria, J. N., … Wahl, D. R. (2020). Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nature Communications, 11(1), 3811. https://doi.org/10.1038/s41467-020-17512-x Cite
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Polydatin Executes Anticancer Effects against Glioblastoma Multiforme by Inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail Signaling Pathway

The authors demonstrated that polydatin repressed cell proliferation, migration, invasion and stemness and promoted apoptosis in glioblastoma multiforme cells.
[Life Sciences]
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Oncogenic Smurf1 Promotes PTEN Wild-Type Glioblastoma Growth by Mediating PTEN Ubiquitylation

Smurf1 promotes cell growth and colony formation by accelerating cell cycle and aberrant signaling pathways. In addition, the authors showed that Smurf1 ubiquitylates and degrades phosphatase and tensin homolog.
[Oncogene]
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Gene Expression Profiling of Glioblastoma Cell Lines Depending on TP53 Status after Tumor-Treating Fields (TTFields) Treatment

Researchers identified the key gene signatures and pathways associated with TTFields in four glioblastoma cell lines varying in TP53 mutation status using gene profiling and functional annotation.
[Scientific Reports]
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Regulated IFN Signalling Preserves the Stemness of Intestinal Stem Cells by Restricting Differentiation Into Secretory-Cell Lineages

Scientists describe a transcriptional regulator that preserves the stemness of intestinal stem cells by restricting their differentiation into secretory-cell lineages.
[Nature Cell Biology]
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A Cytoskeleton Regulator AVIL Drives Tumorigenesis in Glioblastoma

Scientists found that advillin was overexpressed in all the glioblastomas they had tested including glioblastoma stem/initiating cells, but hardly detectable in non-neoplastic astrocytes, neural stem cells or normal brain.
[Nature Communications]
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Combination Therapy with Nanomicellar-Curcumin and Temozolomide for In Vitro Therapy of Glioblastoma Multiforme via Wnt Signaling Pathways

Scientists evaluated the efficacy of a combination of temozolomide plus curcumin or nanomicellar-curcumin on the inhibition of glioblastoma growth in vitro, via effects on autophagy, apoptosis, and the Wnt signaling pathway.
[Journal of Molecular Neuroscience]
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Cell Lineage-Based Stratification for Glioblastoma

Researchers identified corresponding transcriptional profiles in human glioblastoma and describe patient-derived xenografts with species-conserved subtype-discriminating functional properties.
[Cancer Cell]
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Single-Cell RNA-Seq Reveals that Glioblastoma Recapitulates a Normal Neurodevelopmental Hierarchy

Investigators found a conserved neural tri-lineage cancer hierarchy centered around glial progenitor-like cells. They also found that this progenitor population contains the majority of the cancer’s cycling cells, and, using RNA velocity, is often the originator of the other cell types.
[Nature Communications]
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