Inhibition of MUC1 Exerts Cell-Cycle Arrest and Telomerase Suppression in Glioblastoma Cells

The anticancer mechanism of MUC1 suppression in glioblastoma was investigated. The expression level of MUC1 was analyzed in human glioma and paired normal brain tissues.
[Scientific Reports]
Kim, S., Seo, Y., Chowdhury, T., Yu, H. J., Lee, C. E., Kim, K.-M., Kang, H., Kim, H. J., Park, S.-J., Kim, K., & Park, C.-K. (2020). Inhibition of MUC1 exerts cell-cycle arrest and telomerase suppression in glioblastoma cells. Scientific Reports, 10(1), 18238. https://doi.org/10.1038/s41598-020-75457-z Cite
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Exosomal LGALS9 in the Cerebrospinal Fluid of Glioblastoma Patients Suppressed Dendritic Cell Antigen Presentation and Cytotoxic T-Cell Immunity

Researchers found that glioblastoma multiforme-cerebrospinal fluid-exosomes (GBM-CSF-Exos) contained a unique protein, LGALS9 ligand, which bound to the TIM3 receptor of dendritic cells (DCs) in the CSF to inhibit antigen recognition, processing and presentation by DCs, leading to failure of the cytotoxic T-cell-mediated antitumor immune response.
[Cell Death & Disease]
Wang, M., Cai, Y., Peng, Y., Xu, B., Hui, W., & Jiang, Y. (2020). Exosomal LGALS9 in the cerebrospinal fluid of glioblastoma patients suppressed dendritic cell antigen presentation and cytotoxic T-cell immunity. Cell Death & Disease, 11(10), 1–16. https://doi.org/10.1038/s41419-020-03042-3 Cite
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Reduced EGFR and Increased miR-221 Is Associated with Increased Resistance to Temozolomide and Radiotherapy in Glioblastoma

Researchers explored the underlying mechanisms behind treatment resistance and the lack of success with anti-EGFR therapy in the clinic. After generating a number of treatment resistant Glioblastoma cell lines they observed that resistant cell lines lacked EGFR activation and expression.
[Scientific Reports]
Areeb, Z., Stuart, S. F., West, A. J., Gomez, J., Nguyen, H. P. T., Paradiso, L., Zulkifli, A., Jones, J., Kaye, A. H., Morokoff, A. P., & Luwor, R. B. (2020). Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma. Scientific Reports, 10(1), 17768. https://doi.org/10.1038/s41598-020-74746-x Cite
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Endothelial, Pericyte and Tumor Cell Expression in Glioblastoma Identifies Fibroblast Activation Protein (FAP) as an Excellent Target for Immunotherapy

Short‐term cultures of glioma neural stem cells were compared to cultures of healthy astrocytes and neurons using flow cytometry. Glioblastoma tissues were dissociated and analysed by high‐parameter flow cytometry and single‐cell transcriptomics.
[Clinical & Translational Immunology]
Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy - Ebert - 2020 - Clinical & Translational Immunology - Wiley Online Library. (n.d.). Retrieved October 19, 2020, from https://onlinelibrary.wiley.com/doi/10.1002/cti2.1191 Cite
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Tenascin C Promotes Cancer Cell Plasticity in Mesenchymal Glioblastoma

Researchers identified Tenascin C (TNC) to be upregulated and secreted in mesenchymal glioblastoma subtype with high NF-κB signaling activity. Silencing TNC decreased proliferation, migration and suppresses self-renewal of glioma stem cells.
[Oncogene]
Angel, I., Pilo Kerman, O., Rousso-Noori, L., & Friedmann-Morvinski, D. (2020). Tenascin C promotes cancer cell plasticity in mesenchymal glioblastoma. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01506-6 Cite
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Megalencephalic Leukoencephalopathy with Subcortical Cysts 1 (MLC1) Promotes Glioblastoma Cell Invasion in the Brain Microenvironment

The authors showed that Mlc1 was expressed in human stem-like glioblastoma (GBM) cells and was linked to the development of primary and recurrent GBM.
[Oncogene]
Lattier, J. M., De, A., Chen, Z., Morales, J. E., Lang, F. F., Huse, J. T., & McCarty, J. H. (2020). Megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) promotes glioblastoma cell invasion in the brain microenvironment. Oncogene, 1–12. https://doi.org/10.1038/s41388-020-01503-9 Cite
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Single-Cell RNA-Sequencing Shift in the Interaction Pattern between Glioma Stem Cells and Immune Cells during Tumorigenesis

Single-cell sequencing data from seven surgical specimens of glioblastoma patients and patient-derived glioma stem cells co-cultured with peripheral leukocytes were used for the analysis.
[Frontiers in Immunology]
Zhai, Y., Li, G., Li, R., Chang, Y., Feng, Y., Wang, D., Wu, F., & Zhang, W. (2020). Single-Cell RNA-Sequencing Shift in the Interaction Pattern Between Glioma Stem Cells and Immune Cells During Tumorigenesis. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.581209 Cite
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Immunocytokines Are a Promising Immunotherapeutic Approach Against Glioblastoma

Researchers showed that L19 accumulated in the tumor microenvironment of two orthotopic immunocompetent mouse glioma models.
[Science Translational Medicine]
Weiss, T., Puca, E., Silginer, M., Hemmerle, T., Pazahr, S., Bink, A., Weller, M., Neri, D., & Roth, P. (2020). Immunocytokines are a promising immunotherapeutic approach against glioblastoma. Science Translational Medicine, 12(564). https://doi.org/10.1126/scitranslmed.abb2311 Cite
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The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Researchers interrogated N6-methyladenosine (m6A) mRNA modifications in glioma stem cells by methyl RNA-immunoprecipitation followed by sequencing and transcriptome analysis, finding transcripts marked by m6A often upregulated compared to normal neural stem cells.
[Cancer Discovery]
Dixit, D., Prager, B. C., Gimple, R. C., Poh, H. X., Wang, Y., Wu, Q., Qiu, Z., Kidwell, R. L., Kim, L. J. Y., Xie, Q., Vitting-Seerup, K., Bhargava, S., Dong, Z., Jiang, L., Zhu, Z., Hamerlik, P., Jaffrey, S. R., Zhao, J. C., Wang, X., & Rich, J. N. (2020). The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-0331 Cite
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Epigenetic Modulator Inhibition Overcomes Temozolomide Chemoresistance and Antagonizes Tumor Recurrence of Glioblastoma

Investigators identified a specific glioblastoma multiforme stem-like cells subset and showed that activity of these cells was positively regulated by stabilization of methyl CpG binding domain 3 protein.
[Journal of Clinical Investigation]
Moon, B.-S., Cai, M., Lee, G., Zhao, T., Song, X., Giannotta, S. L., Attenello, F. J., Yu, M., & Lu, W. (2020). Epigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma. The Journal of Clinical Investigation, 130(11). https://doi.org/10.1172/JCI127916 Cite
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Patient-Derived Organoids and Orthotopic Xenografts of Primary and Recurrent Gliomas Represent Relevant Patient Avatars for Precision Oncology

Investigators report the establishment a large cohort of unique organoids and patient-derived orthotopic xenografts (PDOX) of various glioma subtypes, including gliomas with mutations in IDH1, and paired longitudinal PDOX from primary and recurrent tumors of the same patient.
[Acta Neuropathologica]
Golebiewska, A., Hau, A.-C., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., Wantz, M., Michelucci, A., Neirinckx, V., Muller, A., Kaoma, T., Nazarov, P. V., Azuaje, F., De Falco, A., Flies, B., … Niclou, S. P. (2020). Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathologica. https://doi.org/10.1007/s00401-020-02226-7 Cite
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