m6A Reader IGF2BP2-Stabilized CASC9 Accelerates Glioblastoma Aerobic Glycolysis by Enhancing HK2 mRNA Stability

MeRIP-Seq revealed the m6A profile in the glioblastoma multiforme (GBM). Moreover, the m6A-related long non-coding RNA CASC9 expression was significantly elevated in the GBM tissue and its ectopic high expression was associated with poor survival, acting as an independent prognostic factor for GBM patients.
[Cell Death Discovery]
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Viability Fingerprint of Glioblastoma Cell Lines: Roles of Mitotic, Proliferative, and Epigenetic Targets

Scientists compared the efficacy of focused modulation of a set of signaling pathways in two glioblastoma cell lines, U-251 MG and T98-G, using a panel of thirteen compounds targeting cell cycle progression, proliferation, epigenetic modifications, and DNA repair mechanism.
[Scientific Reports]
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The Polarity Protein Par3 Coordinates Positively Self-Renewal and Negatively Invasiveness in Glioblastoma

Researchers studied the role of the Par3 protein (encoded by PARD3) in glioblastoma multiforme (GBM). GBM patient transcriptomic data and patient-derived culture analysis indicated diverse levels of expression of PARD3 across and independent from subtypes
[Cell Death & Disease]
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Pyrvinium Pamoate Regulates MGMT Expression through Suppressing the Wnt/β-Catenin Signaling Pathway to Enhance the Glioblastoma Sensitivity to Temozolomide

Investigators found that pyrvinium pamoate (PP) and Temozolomide (TMZ) had synergistic effect on inhibiting the viability of glioblastoma multiforme (GBM) cells, and PP induced inhibition of MGMT and enhanced the TMZ chemosensitivity of GBM cells through down-regulating Wnt/β-catenin pathway.
[Cell Death Discovery]
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Targeting EYA2 Tyrosine Phosphatase Activity in Glioblastoma Stem Cells Induces Mitotic Catastrophe

The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.
[Journal of Experimental Medicine]
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DHHC9-Mediated GLUT1 S-Palmitoylation Promotes Glioblastoma Glycolysis and Tumorigenesis

Scientists found that GLUT1 was palmitoylated at Cys207, and S-palmitoylation was required for maintaining GLUT1 PM localization. They identified DHHC9 as the palmitoyl transferase responsible for this critical posttranslational modification.
[Nature Communications]
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ZBP1-MLKL Necroptotic Signaling Potentiates Radiation-Induced Antitumor Immunity via Intratumoral STING Pathway Activation

Researchers developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release.
[Science Advances]
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Oncogenic Activity of Glucocorticoid Receptor β Is Controlled by Ubiquitination-Dependent Interaction with USP49 in Glioblastoma Cells

By establishing a C-terminal deletion mutant, scientists determined that glucocorticoid receptor β (GRβ) can be ubiquitinated. They also found that its C-terminal was essential for this ubiquitination
[Molecular Cancer Research]
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Epigenetic Encoding, Heritability and Plasticity of Glioma Transcriptional Cell States

Investigators demonstrated heritability of malignant cell states, with key differences in hierarchal and plastic cell state architectures in IDH-mutant glioma versus IDH-wild-type glioblastoma, respectively.
[Nature Genetics]
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Extracellular Vesicles: The Key for Precision Medicine in Glioblastoma

Investigators discuss the limitations of current blioblastoma treatment options and the rationale behind the need for personalized care.
[Neuro-Oncology]
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Adaptive Mechanoproperties Mediated by the Formin FMN1 Characterize Glioblastoma Fitness for Invasion

Scientists identified clones of patient-derived glioma propagating cells that were either highly proliferative or highly invasive and compared their cellular architecture, migratory, and biophysical properties.
[Developmental Cell]
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