Treatment of Kidney Clear Cell Carcinoma, Lung Adenocarcinoma and Glioblastoma Cell Lines with Hydrogels Made of DNA Nanostars

Investigators studied the biological response of three different cell lines to the treatment with DNA-GEL – a DNA-based hydrogel composed of interacting DNA nanostars.
[Biomaterials Science]
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Irradiation Causes Senescence, ATP Release, and P2X7 Receptor Isoform Switch in Glioblastoma

Researchers showed that P2X7A and B receptor isoform levels were inversely modulated during the post-irradiation recovery phase in glioblastoma cells.
[Cell Death & Disease]
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Immunogenic Cell Death and Its Therapeutic or Prognostic Potential in High-Grade Glioma

Glioblastoma (GBM) is the most lethal primary brain tumor with a dismal prognosis despite maximal therapy. The development of new therapies in this aggressive type of tumors remains highly challenging partially due to the cold tumor immune environment. GBM could therefore benefit from immunogenic cell death-based therapies stimulating the anti-tumor immune response.
[Genes & Immunity]
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Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

Researchers interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-derived glioblastoma (GBM) stem cells (GSCs), differentiated GBM cells, and neural stem cells to identify master regulators of GSC stemness.
[Cancer Discovery]
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POLE2 Facilitates the Malignant Phenotypes of Glioblastoma through Promoting AURKA-Mediated Stabilization of FOXM1

The authors revealed crucial roles and a novel mechanism of poly ε-B subunit (POLE2) involved in glioblastoma (GBM) through Aurora kinase A (AURKA)-mediated stability of forkhead transcription factor (FOXM1) and may provide the theoretical basis of molecular therapy for GBM.
[Cell Death & Disease]
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NEK2 Enhances Malignancies of Glioblastoma via NIK/NF-κB Pathway

Scientists found that NEK2 knockdown attenuated cell proliferation, migration, invasion, and tumorigenesis of glioblastoma (GBM) while NEK2 overexpression promoted the GBM progression.
[Cell Death & Disease]
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IL-13Rα2 Humanized scFv-Based CAR T Cells Exhibit Therapeutic Activity against Glioblastoma with Increased Expansion and Reduced Cytokine Production

Investigators constructed a CAR targeting interleukin-13 receptor α2 according to a murine antibody, and then humanized the single-chain variable fragment sequence to generate another CAR.
[Molecular Therapy-Oncolytics]
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Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8+ T Cells and Enhances Survival in Mouse Glioma Models

Researchers assessed regulatory T cells and cytotoxic T lymphocytes in the tumor microenvironment, cervical lymph nodes, spleen, and thymus; and hematopoietic stem and progenitor cells in the bone marrow.
[Clinical Cancer Research]
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TMEM158 Promotes the Proliferation and Migration of Glioma Cells via STAT3 Signaling in Glioblastomas

Researchers found that TMEM158 expression in human glioma cells in the tumor core was significantly higher than that in noncancerous cells at the tumor edge using bioinformatics analysis.
[Cancer Gene Therapy]
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SMURF2 Phosphorylation at Thr249 Modifies Glioma Stemness and Tumorigenicity by Regulating TGF-β Receptor Stability

Researchers demonstrated that SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)Thr249 phosphorylation played an essential role in maintaining glioma stem cell (GSC) stemness and tumorigenicity. SMURF2 silencing augmented the self-renewal potential and tumorigenicity of patient-derived GSCs.
[Communications Biology]
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Quiescent Human Glioblastoma Cancer Stem Cells Drive Tumor Initiation, Expansion, and Recurrence Following Chemotherapy

F3-antibody-sorted glioblastoma cells exhibited stem cell gene expression, enhanced self-renewal in culture, drove tumor initiation and serial transplantation, and reconstituted tumor heterogeneity.
[Developmental Cell]
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