NDUFA4L2 Promotes Glioblastoma Progression, Is Associated with Poor Survival, and Can Be Effectively Targeted by Apatinib

Gene knockdown of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (NDUFA4L2) inhibited tumor cell proliferation and enhanced apoptosis, while tumor cells initiated protective mitophagy in vitro and in vivo.
[Cell Death & Disease]
Chen, Z., Wei, X., Wang, X., Zheng, X., Chang, B., Shen, L., Zhu, H., Yang, M., Li, S., & Zheng, X. (2021). NDUFA4L2 promotes glioblastoma progression, is associated with poor survival, and can be effectively targeted by apatinib. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03646-3 Cite
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Mutation-Specific Non-Canonical Pathway of PTEN as a Distinct Therapeutic Target for Glioblastoma

Researchers established a library of cancer cell lines that overexpressed mutant proteins using the U87MG and patient-derived cell models lacking functional PTEN.
[Cell Death & Disease]
Choi, S. W., Lee, Y., Shin, K., Koo, H., Kim, D., Sa, J. K., Cho, H. J., Shin, H., Lee, S. J., Kim, H., Chung, S., Shin, J., Lee, C., & Nam, D.-H. (2021). Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03657-0 Cite
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ERC-USA Announces FDA Recommendation for Early Termination of Phase II Clinical Trial of ERC1671 (Gliovac or Sitoiganap) and Application for Registration Trial for Treatment of Glioblastoma

ERC-USA and the University of California, Irvine has announced that the FDA has recommended early termination of the onging Phase II clinical trial titled ERC1671/GM-CSF/Cyclophosphamide for the treatment of glioblastoma.
[ERC-USA (Globe Newswire, Inc.)]
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Nitidine Chloride Suppresses Epithelial-Mesenchymal Transition and Stem Cell-Like Properties in Glioblastoma by Regulating JAK2/STAT3 Signaling

Researchers investigated the inhibitory effect of nitidine chloride on the epithelial‐mesenchymal transition process and stem cell‐like properties in glioma cells.
[Cancer Medicine]
Jia, M., Wang, Y., Guo, Y., Yu, P., Sun, Y., Song, Y., & Zhao, L. (n.d.). Nitidine chloride suppresses epithelial-mesenchymal transition and stem cell-like properties in glioblastoma by regulating JAK2/STAT3 signaling. Cancer Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/cam4.3869 Cite
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C3G Downregulation Induces the Acquisition of a Mesenchymal Phenotype That Enhances Aggressiveness of Glioblastoma Cells

The authors report that C3G downregulation promoted the acquisition of a more mesenchymal phenotype that enhanced the migratory and invasive capacity of glioblastoma cells.
[Cell Death & Disease]
Manzano, S., Gutierrez-Uzquiza, A., Bragado, P., Sequera, C., Herranz, Ó., Rodrigo-Faus, M., Jauregui, P., Morgner, S., Rubio, I., Guerrero, C., & Porras, A. (2021). C3G downregulation induces the acquisition of a mesenchymal phenotype that enhances aggressiveness of glioblastoma cells. Cell Death & Disease, 12(4), 1–17. https://doi.org/10.1038/s41419-021-03631-w Cite
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Assessing Fatty Acid-Induced Lipotoxicity and Its Therapeutic Potential in Glioblastoma Using Stimulated Raman Microscopy

The authors evaluated the therapeutic potential of free fatty acid-induced lipotoxicity for the suppression of glioma growth.
[Scientific Reports]
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Role of Glioblastoma Stem Cells in Cancer Therapeutic Resistance: A Perspective on Antineoplastic Agents from Natural Sources and Chemical Derivatives

Scientists describe major intrinsic and extrinsic mechanisms that mediate chemoradioresistant glioblastoma stem cells and therapies based on antineoplastic agents from natural sources, derivatives, and synthetics used alone or in synergistic combination with conventional treatment.
[Current Stem Cell Research & Therapy]
Alves, A. L. V., Gomes, I. N. F., Carloni, A. C., Rosa, M. N., da Silva, L. S., Evangelista, A. F., Reis, R. M., & Silva, V. A. O. (2021). Role of glioblastoma stem cells in cancer therapeutic resistance: a perspective on antineoplastic agents from natural sources and chemical derivatives. Stem Cell Research & Therapy, 12(1), 206. https://doi.org/10.1186/s13287-021-02231-x Cite
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Rapid Reprogramming of Tumor Cells into Cancer Stem Cells on Double-Network Hydrogels

Researchers showed that a double-network hydrogel could rapidly reprogram differentiated cancer cells into cancer stem cells.
[Nature Biomedical Engineering]
Suzuka, J., Tsuda, M., Wang, L., Kohsaka, S., Kishida, K., Semba, S., Sugino, H., Aburatani, S., Frauenlob, M., Kurokawa, T., Kojima, S., Ueno, T., Ohmiya, Y., Mano, H., Yasuda, K., Gong, J. P., & Tanaka, S. (2021). Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nature Biomedical Engineering, 1–12. https://doi.org/10.1038/s41551-021-00692-2 Cite
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Single-Cell Profiling of Myeloid Cells in Glioblastoma across Species and Disease Stage Reveals Macrophage Competition and Specialization

Scientists employed single-cell RNA sequencing and CITE-seq to map the glioblastoma immune landscape in mouse tumors and in patients with newly diagnosed disease or recurrence.
[Nature Neuroscience]
Pombo Antunes, A. R., Scheyltjens, I., Lodi, F., Messiaen, J., Antoranz, A., Duerinck, J., Kancheva, D., Martens, L., De Vlaminck, K., Van Hove, H., Kjølner Hansen, S. S., Bosisio, F. M., Van der Borght, K., De Vleeschouwer, S., Sciot, R., Bouwens, L., Verfaillie, M., Vandamme, N., Vandenbroucke, R. E., … Movahedi, K. (2021). Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nature Neuroscience, 1–16. https://doi.org/10.1038/s41593-020-00789-y Cite
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P-Selectin Axis Plays a Key Role in Microglia Immunophenotype and Glioblastoma Progression

Scientists showed that P-selectin mediated microglia-enhanced glioblastoma proliferation and invasion by altering microglia/macrophages activation state.
[Nature Communications]
Yeini, E., Ofek, P., Pozzi, S., Albeck, N., Ben-Shushan, D., Tiram, G., Golan, S., Kleiner, R., Sheinin, R., Israeli Dangoor, S., Reich-Zeliger, S., Grossman, R., Ram, Z., Brem, H., Hyde, T. M., Magod, P., Friedmann-Morvinski, D., Madi, A., & Satchi-Fainaro, R. (2021). P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression. Nature Communications, 12(1), 1912. https://doi.org/10.1038/s41467-021-22186-0 Cite
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BERG to Conduct Phase II Trial for Treatment Of Deadly Glioblastoma Multiforme (GBM)

BERG Health announced with leading cancer centers that the FDA has authorized a Phase II trial in GBM patients in neo-adjuvant settings using BERG’s BPM 31510.
[BERG Health (PR Newswire, LLC.)]
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