glioblastoma

[Journal of Experimental Medicine] The authors interrogated gene expression profiles from glioblastoma stem cells, differentiated glioblastoma cells, and neural stem cells, revealing EYA2 as preferentially expressed by GSCs.

[Science Advances] Researchers developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release.

[Nature Communications] Scientists found that GLUT1 was palmitoylated at Cys207, and S-palmitoylation was required for maintaining GLUT1 PM localization. They identified DHHC9 as the palmitoyl transferase responsible for this critical posttranslational modification.

[Nature Genetics] Investigators demonstrated heritability of malignant cell states, with key differences in hierarchal and plastic cell state architectures in IDH-mutant glioma versus IDH-wild-type glioblastoma, respectively.

[Molecular Cancer Research] By establishing a C-terminal deletion mutant, scientists determined that glucocorticoid receptor β (GRβ) can be ubiquitinated. They also found that its C-terminal was essential for this ubiquitination

[Neuro-Oncology] Investigators discuss the limitations of current blioblastoma treatment options and the rationale behind the need for personalized care.