hedgehog signaling

[Communications Biology] The identity of a glycinergic synapse was maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptured glycine back to presynaptic terminals to preserve vesicular glycine content. The authors identified the Hedgehog pathway as a robust controller of GlyT2 expression and transport activity.

[Molecular Cancer] CircIPO11 was highly expressed in hepatocellular carcinoma (HCC) tumor tissues and liver cancer stem cells (CSCs), and was required for the self-renewal maintenance of liver CSCs to initiate HCC development.

[Science Advances] Gastrointestinal motility disorders occur frequently in patients with ciliopathy, but the underlying genetic link is unclear. Mechanistically, Kif7 inhibited Gli2 in enteric neural crest cells, where Gli2 positively regulated the expression of Ezh2 by inhibiting the miR124-mediated suppression.

[Nature Communications] Neural-stem cells were isolated from parthenogenetic lizard embryos, rendered unresponsive to Hedgehog signaling via CRISPR/Cas9 gene knockout of smoothened, and implanted back into clonally-identical adults to regulate tail regeneration.

[Cell Death Discovery] Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.

[Nature Communications] Skin wound analysis from Sox9 conditional knock-out mice demonstrates a significant reduction in pathological EndMT resulting in reduced scar area. The converse was observed with Rbpj conditionally knocked-out from the murine vasculature or inhibition of Notch signaling in human endothelial colony forming cells, resulting in enhanced Sox9 and EndMT related gene