hematopoietic stem cells

[Cancer Cell] The authors found that YTHDC1 was the essential N6-Methyladenosine (m6A) reader in myeloid leukemia from a genome-wide CRISPR screen, and that m6A was required for the formation of a nuclear body mediated by phase separation that maintained mRNA stability and controlled cancer cell survival and differentiation.

[Journal of Experimental Medicine] Investigators utilized various methods to understand the effects of age-regulated systemic factors on HSCs and their bone marrow niche.

[Journal of Clinical Oncology] This phase Ib/II study evaluated the safety and efficacy of fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin combined with the B-cell lymphoma-2 inhibitor venetoclax in newly diagnosed patients with acute myeloid leukemia (AML) and relapsed or refractory AML.

[Bone Marrow Transplantation] Investigators reported 236 adult patients who received haploidentical HSC transplantation with post-transplant cyclophosphamide.

[British Journal of Dermatology] The authors discuss the various forms of cell therapy currently available, their utility in the management of immune-mediated inflammatory diseases (IMIDs) and emerging evidence for efficacy in severe psoriasis unresponsive to biologic therapy.

[Orphanet Journal of Rare Diseases] Investigators described five Wolman disease patients diagnosed in infancy that were treated at Royal Manchester Children's Hospital receiving enzyme replacement therapy with dietary substrate reduction then hematopoietic stem cell transplant — multimodal therapy.