[Cancer Gene Therapy] The authors investigated the differential regulatory effect of metabotropic glutamate receptor 5 on chemosensitivity in HCC and chemotoxicity to the normal liver.
[Nature Communications] Researchers showed the citrullination of pancreatic glucokinase as a result of inflammation, triggering autoimmunity and affecting glucokinase biological functions.
[Biomedicine & Pharmacotherapy] Sphaerococcenol A capacity to impact colorectal-CSCs tumorspheres was evaluated by determining tumorspheres viability, number, and area, as well as the proteasome inhibitory activity.
[Cell Death & Disease] The authors identified reverse signaling between glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) as a cross-interaction pathway between immune cells and hepatic stem/progenitor cells that restricted the expansion of hepatic stem/progenitor cells and reduced the possibility of carcinogenesis.
[Cell Stem Cell] Scientists studied heterogeneity of hepatic vascular cells during mouse development through functional and single-cell RNA-sequencing.