hepatic stellate cells

[Acta Pharmacologica Sinica] Researchers investigated the effects of pantoprazole (PPZ), a proton pump inhibitor, against liver fibrosis in a bile duct ligation rat model, human hepatic stellate cell (HSC) line LX-2 and mouse primary HSCs, and explored the potential mechanisms underlying the effects of PPZ in vitro and in vivo.

[Clinical therapeutics] The authors summarize the emerging and more established therapeutic options considering the complex pathophysiology of nonalcoholic fatty liver disease and the important long-term sequelae of this condition.

[Genevant Sciences] Genevant Sciences, a leading nucleic acid delivery company with world-class platforms and the industry’s most robust and expansive lipid nanoparticle patent estate, announced that it has entered into a global collaboration and license agreement with Takeda Pharmaceutical Company Limited for the development and commercialization of novel nonviral gene therapies to treat up to two undisclosed rare liver diseases.

[Digestive and Liver Disease] Scientists summarize the current knowledge of how different crosstalk between liver sinusoidal endothelial cells and other liver cells, including hepatocytes, hepatic stellate cells, macrophoges, immune cells in liver and extra cellular matrix contribute to the physiological function and the progrssion from liver fibrosis to cirrhosis, or even to hepatocellular carcinoma.

[Advanced Drug Delivery Reviews] Reseachers overview recent findings from human study and animal models on the pathophysiological communication among hepatocytes, Kupffer cells, hepatic stellate cells and liver sinusoidal endothelial cells during the disease development.

[Nature Communications] Single-cell transcriptome analysis and FACS analysis revealed CD69+CD103−CD8+ Trm cell enrichment in non-alcoholic steatohepatitis resolution livers.