hepatitis

[Journal of Dental Research] Researchers investigated if xerostomia associated with salivary gland (SG) and hepatitis C virus (HCV) infection and characterized the structural changes in SG and saliva composition.

[Science Advances] Scientists demonstrated that 3D cultured organoids from fetal and adult human liver with cholangiocyte or hepatocyte phenotype supported hepatitis E virus replication.

[Ascletis Pharma, Inc.] Ascletis Pharma, Inc. announced the Investigational New Drug (IND) application approval by US FDA and initiation of global development of ASC22, a first-in-class, subcutaneously administered PD-L1 antibody for functional cure of chronic hepatitis B.

[Cancer Epidemiology Biomarkers & Prevention] Bacterial 16S rRNA sequences were evaluated in oral samples from 90 hepatocellular carcinoma (HCC) cases and 90 controls who were a part of a larger US case–control study of HCC among patients diagnosed from 2011 to 2016. The authors provides novel evidence that oral Cyanobacteria may be an independent risk factor for HCC.

[Aligos Therapeutics, Inc.] Aligos Therapeutics, Inc. announced that it has expanded its ongoing collaboration agreement with Merck to discover and develop oligonucleotide therapies for non-alcoholic steatohepatitis (NASH).

[Molecular Cancer] CRISPR-based loss-of-function genetic screens were used to target 18,053 protein-coding genes in hepatocellular carcinoma cells to identify chemotherapy-related synthetic lethal genes in these cells.