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in vitro

Activin-Mediated Alterations of the Fibroblast Transcriptome and Matrisome Control the Biomechanical Properties of Skin Wounds

[Nature Communications] The authors provided mechanistic insight into the roles of activin in wound repair and fibrosis and identified the functional consequences of alterations in the wound matrisome at the biomechanical level.

Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors

[Cell Stem Cell] Researchers showed integrin-linked kinase, a key constituent of focal adhesions, is highly expressed in TKI-nonresponsive patient cells and their LSCs.

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