Tag results:
insulin
Muscle Cell News
Nampt Activator P7C3 Ameliorates Diabetes and Improves Skeletal Muscle Function Modulating Cell Metabolism and Lipid Mediators
[Journal of Cachexia Sarcopenia and Muscle] Researchers assessed the functional, morphometric, biochemical, and molecular effects of P7C3 treatment in skeletal muscle of type 2 diabetic (db/db) mice.
Pancreatic Cell News
SENP2 Regulates Mitochondrial Function and Insulin Secretion in Pancreatic β Cells
[Experimental and Molecular Medicine] Using a cell culture system of NIT-1, an islet β cell line, scientists found that increased small ubiquitin-like modifier (SUMO) 2/3 conjugation to DRP1 due to SUMO-specific protease 2 (SENP2) deficiency suppressed the phosphorylation of DRP1, which possibly induced mitochondrial dysfunction.
Pancreatic Cell News
Antioxidation of a Proteoglycan from Ganoderma lucidum Protects Pancreatic β-Cells against Oxidative Stress-Induced Apoptosis In Vitro and In Vivo
[International Journal of Biological Macromolecules] Researchers investigated systematically the roles of a proteoglycan from Ganoderma lucidum in protection and repair of pancreatic β-cells against oxidative stress-induced injury and apoptosis on molecular, cellular and animal basis.
Pancreatic Cell News
Urocortin3: Local Inducer of Somatostatin Release and Bellwether of Beta Cell Maturity
[Peptides] Scientists review the mechanistic underpinnings of urocortin 3 signaling, its net effect on islet cell hormone output, as well as its value as a marker for beta cell maturation and functional status.
Muscle Cell News
Enrichment of the Exocytosis Protein STX4 in Skeletal Muscle Remediates Peripheral Insulin Resistance and Alters Mitochondrial Dynamics via Drp1
[Nature Communications] Researchers showed that transgenic skeletal muscle-specific STX4 enrichment in mice reverses established insulin resistance and improves mitochondrial function in the context of diabetogenic stress.
Pancreatic Cell News
SENP2 Regulates Mitochondrial Function and Insulin Secretion in Pancreatic β Cells
[Experimental and Molecular Medicine] Researchers investigated the function of SENP2 in pancreatic β cells by generating a β cell-specific knockout mouse model.