insulin

[Human Cell] Researchers aimed to determine whether human umbilical cord-derived-MSCs-exosomes have a hepatoprotective effect on non-alcoholic fatty liver disease.

[Circulation Research] Despite endothelial cell insulin and insulin like growth factor-1 (IGF-1) resistance, mutant IGF-1R endothelial cell over-expressing mice had enhanced insulin and IGF-1 mediated systemic glucose disposal, lower fasting free fatty acids and triglycerides.

[Communications Biology] Scientists showed a xanthene derivative, DS20060511, induced GLUT4 translocation to the skeletal muscle cell surface, thereby stimulating glucose uptake into the tissue.

[Acta Pharmacologica Sinica] Scientists investigate whether all-trans retinoic acid influenced diabetic progression and its mechanisms using both Goto-Kazizazi rats and INS-1 cells.

[Nature Communications] Scientists showed that upon starvation hepatic p53 was stabilized by O-GlcNAcylation and played an essential role in the physiological regulation of glucose homeostasis.

[Naunyn-Schmiedebergs Archives of Pharmacology] HepG2 and Huh7 cells were treated with different concentrations of L-leucine, L-glutamine, or L-methionine and cell viability was determined using MTT assay. Insulin-like growth factor 1, phosphorylated ribosomal protein S6 kinase, p53, and cyclin D1 protein levels were assayed using ELISA.