intestinal cells

[Nature] Researchers showed that dietary fructose improved the survival of intestinal cells and increased intestinal villus length in several mouse models. In hypoxic intestinal cells, fructose 1-phosphate inhibited the M2 isoform of pyruvate kinase to promote cell survival.

[Scientific Reports] Investigators show a comprehensive transcriptome-wide characterization of mouse gut organoids derived from different intestinal compartments and from mice of different gender and age.

[Clinical Gastroenterology and Hepatology] Mouse intestinal organoids and dextran sulfate sodium-induced colitis mouse model were used to assess the effects of recombinant soluble thrombomodulin on proliferation of intestinal epithelial cells.

[Journal of Crohn's and Colitis] Expression of GATA-binding factor 6 (GATA6), a transcription factor involved in intestinal epithelial cell differentiation, was evaluated in colon samples taken from healthy controls and IBD patients by real-time PCR and immunohistochemistry.

[PLoS Pathogens] Researchers showed that C. jejuni released a potent pro-inflammatory compound into its environment, which activated an NF-κB-mediated pro-inflammatory response including the induction of CXCL8, CXCL2, TNFAIP2 and PTGS2.

[Frontiers in Cell and Developmental Biology] Based on the results of a bibliometric analysis of intestinal organoids applications, scientists systematically summarized the latest advances and analyzed the limitations and prospects.