Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Look into Treatment Mechanism and Therapeutic Potential

Researchers show the transplantation protocol for mesenchymal stem cells (MSCs), discuss the potential therapeutic mechanisms, and summarize clinical trials on MSCs for treating ischemic stroke.
[Journal of Neurology]
Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J. (2020). Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential. Journal of Neurology. https://doi.org/10.1007/s00415-020-10138-5 Cite
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The Conditioned Medium of Human Embryonic Stem Cell‐Derived Mesenchymal Stem Cells Alleviates Neurological Deficits and Improves Synaptic Recovery in Experimental Stroke

Researchers investigated the effect of CM derived from human embryonic MSCs on experimental ischemic stroke.
[Journal of Cellular Physiology]
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Sovateltide (IRL-1620) Activates Neuronal Differentiation and Prevents Mitochondrial Dysfunction in Adult Mammalian Brains Following Stroke

Investigators showed a novel role of endothelin B receptors in neuronal progenitor cells and mitochondrial fate determination in cerebral ischemia, and in improving neurological deficit after stroke.
[Scientific Reports]
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