NogoA-Expressing Astrocytes Limit Peripheral Macrophage Infiltration after Ischemic Brain Injury in Primates

Utilizing single-nuclei transcriptomics to characterize astrocytes after ischemic stroke in the visual cortex of the marmoset monkey, researchers observed nearly complete segregation between stroke and control astrocyte clusters.
[Nature Communications]
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Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke

Mesenchymal stem cell (MSC) transplantation therapy, which can trigger neuronal regeneration and repair, has been considered as a significant advance in treatment of ischemic stroke.
[Stem Cells International]
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Clonal Hematopoiesis Is Associated With Higher Risk of Stroke

Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease–related morbidity and mortality. Researchers found that CHIP was associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke.
[Stroke]
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CircSKA3 Acts as a Sponge of miR-6796-5p to Be Associated with Outcomes of Ischemic Stroke by Regulating MMP9 Expression

The authors screened the circular RNAs (circRNA) influencing matrix metalloproteinase-9 (MMP9) through the competing endogenous RNA network and evaluated the prognostic value of these circRNAs for acute ischemic stroke.
[European Journal of Neurology]
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Insights of Extracellular Vesicles of Mesenchymal Stem Cells: A Prospective Cell-Free Regenerative Medicine for Neurodegenerative Disorders

Due to paucity of standard protocols in extraction procedures of extracellular vesicles (EVs) and their pharmacological properties and mechanisms, the development of new EV dependent therapies is challenging.
[Molecular Neurobiology]
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Age-Related Immune Alterations and Cerebrovascular Inflammation

The authors describe the current knowledge of the effects of aging on the immune system and the cerebral vasculature and how these changes alter the immune response to stroke and vascular dementia in animal and human studies.
[Molecular Psychiatry]
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Hypoxic Postconditioning Promotes Neurogenesis by Modulating the Metabolism of Neural Stem Cells after Cerebral Ischemia

Researchers investigated whether hypoxic postconditioning (HPC) could promote neurogenesis after ischemic stroke, and to investigate the role of neuronal stem cell metabolism in HPC-induced neuroprotection.
[Experimental Neurology]
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AIM/CD5L Attenuates DAMPs in the Injured Brain and Thereby Ameliorates Ischemic Stroke

Investigators reported that AIM protein reduced sterile inflammation by attenuating damage-associated molecular patterns and that AIM administration ameliorated the deleterious effects of ischemic stroke.
[Cell Reports]
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GNT Pharma Announces Approval of IND Application for the Phase III RODIN Trial of Nelonemdaz for Acute Ischemic Stroke Patients

GNT Pharma Inc. reported that the Korea Ministry of Food and Drug Safety has approved the Investigational New Drug Application for a phase III study of nelonemdaz for acute ischemic stroke patients.
[GNT Pharma Inc. (BusinessWire, Inc.)]
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Strategies to Improve the Efficiency of Transplantation with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke: A Review of Recent Progress

The authors provide an overview of recent scientific reports concerning novel strategies that promote MSC transplantation as an effective therapeutic approach, including physical approaches, chemical agents, traditional Chinese medicines and extracts, and genetic modification.
[Stem Cells International]
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Increased Expression of Fragmented tRNA Promoted Neuronal Necrosis

Through a genome-wide small RNA sequencing, researchers identified several tRNA-derived fragments and piwi-interacting RNA species were enriched in glutamate-induced neuronal necrosis in rat primary neuron cultures, and this enrichment was dependent on the H3K4me3 increase.
[Cell Death & Disease]
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