islets

[Autoimmunity] Scientists reported the use of MSCs for the production and delivery of Gastrin, a peptide hormone that is produced by intestinal cells and fetal islets and can increase β-cell mass, to promote protection from type 1 diabetes.

[Nature Reviews Gastroenterology & Hepatology] Weight loss-induced decrease of intra-pancreatic fat is tightly associated with remission of type 2 diabetes mellitus and its re-deposition with recurrence of the disease.

[Biomedicine & Pharmacotherapy] Scientists investigated whether Abn-CBD can modulate the inflammatory response during type 1 diabetes (T1D) onset using a mouse model of T1D and of beta cell damage.

[eLife] Researchers indicate that microtubules (MTs) stability in the β-cell population was heterogenous, and that glucose-stimulated insulin secretion was suppressed in cells with highly stable MTs.

[Oncogenesis] Scientists reported development of an inducible, conditional mouse model of PanNETs by using a bi-transgenic system for regulated expression of the aberrant activator of Cdk5, p25, specifically in β-islet cells.

[Cell Stem Cell] The authors reported an analysis on one year of data from the first cohort of 15 patients from a single trial site that received subcutaneous implantation of cell products combined with an immunosuppressive regimen.