leukemia cells

[Blood] Investigators showed that concurrent ASXL1 and NRAS mutations defined a population of chronic myelomonocytic leukemia patients with shorter leukemia-free survival than those with ASXL1 mutation only.

[Journal of the American Chemical Society] Scientists synthesized gold nanorods (GNRs) of different aspect ratios and used a binary surfactant mixture of hexadecyltrimethylammonium bromide and sodium oleate. Surface functionalization was followed by chitosan and GNRa-CSP12 selectively taken up by leukemia cells via targeted endocytosis.

[Cancer Cell International] The authors take a look at the latest advances in the use of chitosan in the treatment and improvement of leukemia.

[Cell Death Discovery] Researchers performed high-throughput screening and identified that oridonin, an ent-kaurene diterpenoid extracted from the Chinese herb Rabdosia rubescens, inhibited DNMT3A R882 mutant leukemic cells at a low-micromolar concentration.

[BMC Cancer] Investigators conducted microarray gene expression analysis and compared FX-9 exposed and unexposed prostate cancer cells, followed by pathway analysis and gene annotation to functional processes.

[Cellular & Molecular Immunology] The authors found that posttransplant treatment with the CXCR4 antagonist AMD3100 significantly improved the eradication of leukemia cells in the bone marrow in patient-derived xenograft mice grafted with B cell acute lymphoblastic leukemia cells from multiple patients.