leukemia stem cells

[Biochemical Pharmacology] Scientists discuss the relative dependency that acute myeloid leukemia (AML) cells have on mitochondrial function, and the ability to pivot this reliance to target important subsets of AML cells, including leukemia stem cells.

[Autophagy] Scientists review studies on the role of autophagy in acute myeloid leukemia (AML) development and summarize the linkage between autophagy and several recurrent genetic abnormalities in AML, highlighting the potential of capitalizing on autophagy modulation in targeted therapy for AML.

[Autophagy] Scientists review studies on the role of autophagy in acute myeloid leukemia (AML) development and summarize the linkage between autophagy and several recurrent genetic abnormalities in AML, highlighting the potential of capitalizing on autophagy modulation in targeted therapy for AML.

[Cell Stem Cell] Detailed metabolomic analysis revealed elevated nicotinamide metabolism in relapsed leukemia stem cells (LSCs), which activated both amino acid metabolism and fatty acid oxidation to drive OXPHOS, thereby providing a means for LSCs to circumvent the cytotoxic effects of venetoclax and azacitidine therapy.

[Nature Medicine] Scientists demonstrated that leukemia stem cells upregulated the tumor necrosis factor family ligand CD70 in response to hypomethylating agent treatment resulting in increased CD70/CD27 signaling.

[Blood] By comparing leukemic stem cells (LSCs) to leukemic blasts and healthy hematopoietic stem and progenitor cells (HSPCs), researchers validated candidate LSC markers and highlight novel and potentially targetable proteins that are absent or only lowly expressed in HSPCs.