liver fibrosis

[Scientific Reports] Researchers investigated the association between the histopathological severity of nonalcoholic fatty liver disease (NAFLD) and carotid intima-media thickness in Japanese patients with liver biopsy-proven NAFLD.

[Advanced Drug Delivery Reviews] Reseachers overview recent findings from human study and animal models on the pathophysiological communication among hepatocytes, Kupffer cells, hepatic stellate cells and liver sinusoidal endothelial cells during the disease development.

[Nature Communications] Single-cell transcriptome analysis and FACS analysis revealed CD69+CD103−CD8+ Trm cell enrichment in non-alcoholic steatohepatitis resolution livers.

[Stem Cell Research & Therapy] Researchers investigated the therapeutic potential of human umbilical cord-derived MSCs in acute-on-chronic liver injury (ACLI) and ACLF rat models.

[CytoDyn, Inc.] CytoDyn, Inc., a biotechnology company developing leronlimab, a CCR5 antagonist, announced its clinical trial with leronlimab in combination with carboplatin for the treatment of metastatic TNBC has advanced from Phase Ib to a Phase II trial.

[Expert Review of Gastroenterology & Hepatology] The authors summarized the recent progress in the understanding of the regulatory role of nuclear receptors in hepatic stellate cells and their potential as drug targets in liver fibrosis.