liver fibrosis

[Cell Reports] The authors suggested that infiltrative monocytes promoted fibrogenesis in nonalcoholic fatty liver disease via ADA2-mediated autocrine/paracrine signaling culminating in enhanced PDGF-B production.

[Stem Cells and Development] Investigators explored the possible mechanism of hepatocyte growth factor-transfectedhuman umbilical cord mesenchymal stem cells in inhibiting the proliferation and activation of hepatic stellate cells-T6.

[Nature Communications] Researchers showed that human hepatic organoids, engineered to express the most common causative mutation for Autosomal Recessive Polycystic Kidney Disease (ARPKD), developed the key features of ARPKD liver pathology in only 21 days.

[Oncodesign] Oncodesign and TiumBio have announced the signature of a research collaboration agreement on R&D of potential drug candidates for fibrosis. Under this agreement, Oncodesign will be responsible for identification, chemical synthesis and optimization of Nanocyclix® drug candidates and their early-stage analysis.

[iScience] Investigators optimized the in vitro liver fibrotic niches and subsequently harvested their bioactive ingredients as niche extracts

[Nutrition & Diabetes] Scientists investigated whether growth differentiation factor-15 (GDF-15) concentrations were associated with liver fibrosis and involved in the relationship between Type 2 diabetes mellitus (T2DM) and liver fibrosis, as well as what factors linked with T2DM were associated with increased GDF-15 concentrations.