lymphatic endothelial cells

[Journal of Clinical Investigation] The authors identified that bladder cancer (BCa) cell-secreted extracellular vesicles mediated the intercellular communication with human lymphatic endothelial cells through the transmission of a long noncoding RNA ELNAT1, and promoted lymphangiogenesis and LN metastasis in a SUMOylation-dependent manner in both cultured BCa cell lines and mouse models.

[Stem Cell Research & Therapy] Investigators performed expression profiling of exosome-miRNAs from human umbilical cord mesenchymal stem cells (MSCs) and murine compact bone MSCs to investigate their immunoregulation effects in acute graft-versus-host disease.

[Developmental Cell] Scientists discuss recent insights into new players whose identification has contributed to deciphering the lymphatic regulatory code.

[Scientific Reports] The authors investigated molecular mechanisms that altered the growth and metabolism of isolated lymphatic endothelial cells exposed to prolonged pathologically elevated lymph flow in vivo within the anatomic and physiologic context of a large animal model of congenital heart disease with increased pulmonary blood flow using in vitro approaches.

[Developmental Dynamics] The authors established a novel zebrafish transgenic line expressing eGFP under the control of part of the zebrafish Basic Leucine Zipper ATF‐Like Transcription Factor 3 (batf3) promoter. Spatiotemporal examination of Tg(batf3MIN:eGFP) transgenic fish revealed a typical lymphatic expression pattern, which does not perfectly recapitulate the expression pattern of existing lymphatic endothelial cell transgenic lines.

[Molecular Therapy] Scientists report a mechanistic model via which cervical cancer-secreted, exosome-encapsulated miR-1468-5p promoted lymphatic PD-L1 upregulation and lymphangiogenesis to impair T cell immunity.