lymphocytes

[Drug Discovery Today] Scientists provide a concise overview of the main principles and potential of cell tracking, followed by a discussion of the clinically relevant labeling strategies and their application in adoptive T cell therapies (ACT).

[Trends in Immunology] The authors review the progress in defining the key developmental and functional attributes of type 1 conventional dendritic cells (cDC1s) and the approaches to optimizing the potency of cDC1s for anticancer immunity.

[Molecular Therapy-Methods & Clinical Development] In mouse models, AAV-CAR Tregs mediated continued transgene expression from an immunogenic capsid, despite antibody responses, produced immunosuppressive cytokines, and decreased tissue inflammation.

[Diabetologia] Researchers profiled CD4+ regulatory T cells in a small but well-characterized cohort of extreme slow progressors with a median age 43, followed up for 18–32 years.

[EMBO Reports] Using a single somatic copy number alteration score inclusive of whole-chromosome, chromosome arm, and focal alterations in a pan-cancer analysis of 9,375 samples in The Cancer Genome Atlas database, scientists found an inverse correlation with a cytotoxicity score across disease stages.

[Cancer Immunology Research] New approaches to enhance the utility of immunotherapy are needed. T cell activation and differentiation status are tightly controlled at the transcriptional, epigenetic, and metabolic levels.