macrophages

[Science] Scientists found that resident macrophage deficiency prevents storage of lipids in adipocytes from wild-type and Ccr2–/– mice fed a high-fat diet, as well as hyperphagic leptin receptor–deficient mice.

[inflammopharmacology] The authors review the various molecular pathways, and genetic relevance of mRNA expression of fetuin-A which is correlated with progression of non-alcoholic fatty liver disease (NAFLD).

[Communications Biology] The antifibrotic effect of auranofin was assessed in thioacetamide- and carbon tetrachloride-induced liver fibrosis models. Hepatic stellate cell, bone marrow-derived macrophage, kupffer cell, and hepatocyte were used to examine the underlying mechanism of auranofin.

[Scientific Reports] Scientists demonstrated that YIV-906 plus anti-PD1 could eradicate all Hepa 1–6 tumors in all tumor bearing mice. YIV-906 was found to have multiple mechanisms of action to enhance adaptive and innate immunity.

[Journal of Clinical Investigation] Tumor cell SLIT2 knockdown inhibited macrophage invasion and promoted a cytotoxic gene expression profile, which improved tumor vessel function and enhanced efficacy of chemotherapy and immunotherapy.

[Scientific Reports] The authors examined 42 renal biopsy samples representing endocapillary proliferative lesions from post-streptococcal acute glomerulonephritis, Henoch–Schönlein purpura nephritis, and lupus nephritis