mammary cells

[Cell Death & Disease] In silico analysis showed that epithelial membrane protein 3 (EMP3) was associated with favorable survival, and negatively regulated cell cycle S-phase. Loss and gain of function studies demonstrated that EMP3 inhibited breast cancer cell S-phage entry, DNA replication, DNA damage repair, and stem-like properties.

[Scientific Reports] Scientists performed immune profiling to compare immune-related gene expression between ductal carcinoma in situ and invasive carcinoma of the breast using nCounter PanCancer immune Profiling Panel and found that CXCL10 was the most significant gene that had the highest difference in expression between them.

[Science Translational Medicine] Researchers showed that patients with breast cancer did not accumulate sufficient intratumoral paclitaxel to induce mitotic arrest in tumor cells. Instead, clinically relevant concentrations induced multipolar mitotic spindle formation.

[Molecular Cancer Research] To elucidate the underlying mechanisms that drive breast cancer stem cells (BCSCs) tumorigenicity in TNBC, scientists identified the long noncoding RNA BMP/OP-Responsive Gene (BORG) as an enhancer of BCSC phenotypes.

[Open Biology] To identify novel small molecules that inhibit microtubule organization, investigators conducted sequential phenotypic screening of fission yeast and human cells and showed that one of the compounds, L1, bound to the colchicine-binding site of microtubules and exhibited a preferential potency against a panel of human breast cancer cell lines compared with a control non-cancer cell line.

[Breast Cancer Research] By knocking down the expression of TAZ in TNBC cells, researchers found that TAZ is essential for the maintenance of telomeres in TNBC cells and that loss of TAZ caused senescence phenotype of TNBC cells.