The authors demonstrated that the endothelin-endothelin receptor B signaling pathway conferred resistance to MAPK pathway inhibitors in BRAF mutated melanoma.
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Inhibition of endothelin-B receptor signaling synergizes with MAPK pathway inhibitors in BRAF mutated melanoma | Oncogene. (n.d.). Retrieved January 27, 2021, from https://www.nature.com/articles/s41388-020-01628-x Cite
Investigators showed that MITF, the master transcription factor in melanocytes, controls ubiquitination in melanoma cells. They identified FBXO32, a component of the SCF E3 ligase complex as a new MITF target gene.
[Cell Death & Differentiation]
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Habel, N., El-Hachem, N., Soysouvanh, F., Hadhiri-Bzioueche, H., Giuliano, S., Nguyen, S., Horák, P., Gay, A.-S., Debayle, D., Nottet, N., Béranger, G., Paillerets, B. B., Bertolotto, C., & Ballotti, R. (2021). FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells. Cell Death & Differentiation, 1–12. https://doi.org/10.1038/s41418-020-00710-x Cite
Scientists combined bulk RNA sequencing, single cell RNA sequencing, and bioinformatic analyses, including weighted gene co-expression analysis, to investigate the gene regulatory networks regulating human iPSC differentiation under chondrogenic conditions.
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The authors investigated the effects of electromagnetic fields with long-term evolution and 5G bandwidth on skin pigmentation in vitro.
[International Journal of Molecular Sciences]
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The authors summarize the latest insights into various forms of melanocytes death in vitiligo and discuss the corresponding mechanisms.
[Pigment Cell & Melanoma Research]
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Wu, X., Yang, Y., Xiang, L., & Zhang, C. (n.d.). The fate of melanocyte: mechanisms of cell death in vitiligo. Pigment Cell & Melanoma Research, n/a(n/a). https://doi.org/https://doi.org/10.1111/pcmr.12955 Cite
Investigators discuss the pathways governing epithelial and follicular pigmentation, numerous areas of future research and potential points of intervention are highlighted.
Researchers examined the effect of Lotus seedpod extract (LSE) on melanogenesis and the involved signaling pathways in vitro and in vivo. They showed that non-cytotoxic doses of LSE and its main component epigallocatechin reduced both tyrosinase activity and melanin production in the α-melanocyte stimulating hormone-induced melanoma cells.
Investigators review the potential roles of the unfolded protein response/integrated stress response in the etiology of melanoma and vitiligo.
[Pigment Cell & Melanoma Research]
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Manga, P., & Choudhury, N. (n.d.). The Unfolded Protein and Integrated Stress Response in Melanoma and Vitiligo. Pigment Cell & Melanoma Research, n/a(n/a). https://doi.org/https://doi.org/10.1111/pcmr.12947 Cite
Scientists analyze four major signaling pathways implicated in melanomagenesis, TGF-β, MAPK, Wnt/β-catenin and Hyppo signaling, from the complementary point of view of tumor cells and the microenvironment.
The authors used single-cell RNA sequencing with comparative gene expression analysis to elucidate the transcriptional dynamics of melanocyte stem cells through quiescence, activation, and melanocyte maturation.
[Genes & Development]
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Researchers found that the microscopic appearance of hair follicles without melanocyte stem cells and descendant melanocytes as well as macroscopic appearances of hair graying in RET‐transgenic mice carrying RET oncogene were in accordance with previously reported results for hair graying in humans.
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Hair graying with aging in mice carrying oncogenic RET - Iida - - Aging Cell - Wiley Online Library. (n.d.). Retrieved November 9, 2020, from https://onlinelibrary.wiley.com/doi/10.1111/acel.13273 Cite