Skin Protein-Derived Peptide-Conjugated Vesicular Nanocargos for Selected Skin Cell Targeting and Consequent Activation

Investigators selectively conjugated several skin protein-derived cell-targeting peptides, including KTTKS, NAP-amide, and Lam332, to amphiphilic polymer-reinforced lipid nanovesicles to specifically target fibroblasts, melanocytes, and keratinocytes, respectively, through effective association with the corresponding cell membrane receptors.
[Journal of Materials Chemistry B]
Cho, J. H., Kang, J. Y., Kim, S., Baek, H. R., Kim, J., Jang, K.-S., & Kim, J. W. (2021). Skin protein-derived peptide-conjugated vesicular nanocargos for selected skin cell targeting and consequent activation. Journal of Materials Chemistry B. https://doi.org/10.1039/D1TB00935D Cite
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Propionic Acid Produced by Cutibacterium acnes Fermentation Ameliorates Ultraviolet B-Induced Melanin Synthesis

The authors identified a natural acidic formulation to reduce skin pigmentation. The metabolite propionic acid was the most abundant fatty acid in the filtrate from Pluronic F68 fermentation of Cutibacterium acnes and reduced the DOPA-positive melanocytes by significantly inhibiting cellular tyrosinase activity via binding to the free fatty acid receptor 2.
[Scientific Reports]
Kao, H.-J., Wang, Y.-H., Keshari, S., Yang, J. J., Simbolon, S., Chen, C.-C., & Huang, C.-M. (2021). Propionic acid produced by Cutibacterium acnes fermentation ameliorates ultraviolet B-induced melanin synthesis. Scientific Reports, 11(1), 11980. https://doi.org/10.1038/s41598-021-91386-x Cite
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Non-coding RNAs in Melanoma: Biological Functions and Potential Clinical Applications

The authors summarize the recent research progress on the effects of non-coding RNAs (ncRNAs) on melanoma and attempt to elucidate the role of ncRNAs as molecular markers or potential targets will provide promising application perspectives of melanoma.
[Molecular Therapy-Oncolytics]
Peng, Q., & Wang, J. (2021). Non-Coding RNAs in Melanoma: Biological Functions and Potential Clinical Applications. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.05.012 Cite
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The Protective Role of MC1R in Chromosome Stability and Centromeric Integrity in Melanocytes

Investigators demonstrated that melanocortin-1 receptor (MC1R) is a critical factor in chromosome stability and centromere integrity in melanocytes. α-MSH/MC1R stimulation prevents melanocytes from UV radiation-induced damage of chromosome stability and centromere integrity.
[Cell Death Discovery]
Li, X., Mao, W., Chen, J., Goding, C. R., Cui, R., Xu, Z.-X., & Miao, X. (2021). The protective role of MC1R in chromosome stability and centromeric integrity in melanocytes. Cell Death Discovery, 7(1), 1–9. https://doi.org/10.1038/s41420-021-00499-9 Cite
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Effect of Hypoxia Factors Gene Silencing on ROS Production and Metabolic Status of A375 Malignant Melanoma Cells

Researchers detected a significantly reduced A375 cell viability, an increase in alanine, inositol, nucleotides, and other metabolites that together define apoptosis.
[Scientific Reports]
Špaková, I., Rabajdová, M., Mičková, H., Graier, W. F., & Mareková, M. (2021). Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells. Scientific Reports, 11(1), 10325. https://doi.org/10.1038/s41598-021-89792-2 Cite
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Hypoxia-Dependent Drivers of Melanoma Progression

The authors review the latest progress in hypoxia-regulated pathways involved in the development and progression of all melanoma subtypes.
[Journal of Experimental & Clinical Cancer Research]
D’Aguanno, S., Mallone, F., Marenco, M., Del Bufalo, D., & Moramarco, A. (2021). Hypoxia-dependent drivers of melanoma progression. Journal of Experimental & Clinical Cancer Research, 40(1), 159. https://doi.org/10.1186/s13046-021-01926-6 Cite
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A Protective Role for Autophagy in Vitiligo

Researchers provide the first evidence that autophagy occured in melanocytes and fibroblasts from non-lesional skin of vitiligo patients, as a result of metabolic surveillance response.
[Cell Death & Disease]
Bastonini, E., Kovacs, D., Raffa, S., delle Macchie, M., Pacifico, A., Iacovelli, P., Torrisi, M. R., & Picardo, M. (2021). A protective role for autophagy in vitiligo. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03592-0 Cite
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A Role for Dynlt3 in Melanosome Movement, Distribution, Acidity and Transfer

The level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signaling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer.
[Communications Biology]
Aktary, Z., Conde-Perez, A., Rambow, F., Di Marco, M., Amblard, F., Hurbain, I., Raposo, G., Delevoye, C., Coscoy, S., & Larue, L. (2021). A role for Dynlt3 in melanosome movement, distribution, acidity and transfer. Communications Biology, 4(1), 1–15. https://doi.org/10.1038/s42003-021-01917-5 Cite
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Exosomal miR-106b-5p Derived from Melanoma Cell Promotes Primary Melanocytes Epithelial-Mesenchymal Transition through Targeting EphA4

miR-106b-5p was enriched in melanoma cell-secreted exosomes and transferred to melanocytes. Exosomal miR-106b-5p promoted the epithelial-to-mesenchymal transition, migration, invasion and adhesion of melanocytes. Exosomal miR-106b-5p exerted its role by targeting erythropoietin-producing hepatocellular carcinoma receptor A4 (EphA4) to activate the ERK pathway.
[Journal of Experimental & Clinical Cancer Research]
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A Computer-Guided Design Tool to Increase the Efficiency of Cellular Conversions

Researchers introduced a computer-guided design tool that combines a computational framework for prioritizing more efficient combinations of instructive factors of cellular conversions, called IRENE, with a transposon-based genomic integration system for efficient delivery.
[Nature Communications]
A computer-guided design tool to increase the efficiency of cellular conversions | Nature Communications. (n.d.). Retrieved March 17, 2021, from https://www.nature.com/articles/s41467-021-21801-4 Cite
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RAF-Mutant Melanomas Differentially Depend on ERK2 over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

Investigators demonstrated that ERK2 drove BRAF-mutant melanoma gene expression and proliferation as a function of its higher expression compared to ERK1.
[Molecular Cancer Research]
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