MMP-9 Drives the Melanomagenic Transcription Program through Histone H3 Tail Proteolysis

Investigators reported that matrix metalloproteinase 9 (MMP-9) localized to the nucleus of melanoma cells and potentiated gene expression by proteolytically clipping the histone H3 N-terminal tail.
[Oncogene]
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p32 Promotes Melanoma Progression and Metastasis by Targeting EMT Markers, Akt/PKB Pathway, and Tumor Microenvironment

The authors identified the role of p32 in the malignancy of both murine and human melanoma and found that p32 knockdown led to reduced cell proliferation, migration, and invasion in murine and human melanoma cells.
[Cell Death & Disease]
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Building and Maintaining the Skin

Investigators review diverse cellular interactions and highlight how far-reaching signals can be transmitted at the local level to enable skin stem cells to tailor their actions to suit the particular occasion and optimize fitness.
[Cold Spring Harbor Perspectives in Biology]
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The Current Challenges on Spray-Based Cell Delivery to the Skin Wounds

Keratinocytes, fibroblasts, melanocytes, and mesenchymal stem cells (MSCs) are promising cell sources for cell spray procedures. Scientists focus on the different types of cells and spray instruments used in cell delivery procedures.
[Tissue Engineering Part C-Methods]
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CXCL9 as a Key Biomarker of Vitiligo Activity and Prediction of the Success of Cultured Melanocyte Transplantation

Scientists investigated the potential biomarkers of vitiligo by evaluating the disease activity and curative effect of autologous cultured pure melanocyte transplantation on patients.
[Scientific Reports]
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Human Amniotic Stem Cells-Derived Exosmal miR-181a-5p and miR-199a Inhibit Melanogenesis and Promote Melanosome Degradation in Skin Hyperpigmentation, Respectively

Scientists reported that both human amniotic stem cells and their conditional medium had a potent anti-hyperpigmentation in skin in vivo and in vitro.
[Stem Cell Research & Therapy]
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scRNA-Seq of Human Vitiligo Reveals Complex Networks of Subclinical Immune Activation and a Role for CCR5 in Treg Function

Scientists performed single-cell RNA sequencing on affected and unaffected skin from patients with vitiligo, as well as healthy controls, to define the role of each cell type in coordinating autoimmunity during disease progression.
[Science Translational Medicine]
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Developmental Chromatin Programs Determine Oncogenic Competence in Melanoma

Using a combination of a human PSC–derived cancer model along with zebrafish transgenesis, researchers demonstrated that the transforming ability of BRAFV600E along with additional mutations depended on the intrinsic transcriptional program present in the cell of origin.
[Science]
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Human Melanocyte Development and Melanoma Dedifferentiation at Single-Cell Resolution

Researchers used a single-cell enrichment and RNA-sequencing pipeline to study human epidermal melanocytes directly from the skin, capturing transcriptomes across different anatomical sites, developmental age, sexes and multiple skin tones.
[Nature Cell Biology]
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The Relationship between Melanin Production and Lipofuscin Formation in Tyrosinase Gene Knockout Melanocytes Using CRISPR/Cas9 System

Scientists investigated the relationship between melanin production and lipofuscin synthesis in normal mouse melanoma cell line B16F1 cells and Tyrosinase gene knockout cells.
[Life Sciences]
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CDK7 and MITF Repress a Transcription Program Involved in Survival and Drug Tolerance in Melanoma

The authors showed that dedifferentiation of melanocytic-type melanoma cells into mesenchymal-like cells and acquisition of tolerance to targeted therapies was achieved through chronic inhibition of CDK7.
[EMBO Reports]
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