mesenchymal cells

[Circulation] Genetic fate mapping results revealed that a subset of cardiac endothelial cells transiently expressed αSMA and Zeb1 during embryonic valve formation and transdifferentiated into mesenchymal cells through EndoMT.

[Nature Metabolism] Using cultured mesenchymal and cancer cells, as well as mouse allograft models, the authors provide evidence that extracellular lactate could be utilized by fibroblasts to maintain tricarboxylic acid cycle anaplerosis and non-essential amino acid biosynthesis through pyruvate carboxylase activity.

[Cell Biology International] Scientists investigated the expression of N-Cadherin, a trans-membrane protein that enhanced the cell adhesion and recently gained attention for differentiation and augmentation of stem cell function, in mouse cardiac MSCs.

[Science Advances] Scientists demonstrated that Lyve-1+ tumor-associated macrophages supported tumor growth and identified a pivotal role for these cells in maintaining a population of perivascular mesenchymal cells that expressed α-smooth muscle actin and phenotypically resembled pericytes.

[Scientific Reports] Researchers demonstrated the major role of PPP1R15A in the regulation of lung mesenchymal cells, and regulation of PPP1R15A may represent a novel therapeutic strategy in idiopathic pulmonary fibrosis.

[Journal of Allergy and Clinical Immunology] Scientists generated human thymic epithelial progenitors from human embryonic stem cells and to assess their thymopoietic function in vivo.