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mesenchymal stem cells

METTL3-Mediated LINC00657 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells via miR-144-3p/BMPR1B Axis

[Cell and Tissue Research] Methyltransferase-like 3 (METTL3) facilitated osteogenic differentiation of bone marrow MSCs via the LINC00657/miR-144-3p/BMPR1B axis.

Engineered Delivery of Dental Stem Cell-Derived Extracellular Vesicles for Periodontal Tissue Regeneration

[Advanced Healthcare Materials] Investigators developed a delivery platform for small extracellular vesicles derived from gingival MSCs to treat periodontitis.

Exosomes Derived from Bone Mesenchymal Stem Cells Attenuate Myocardial Fibrosis Both In Vivo and In Vitro via Autophagy Activation: The Key Role of miR-199a-3p/mTOR...

[Human Cell] Scientists investigated the antifibrosis effects of exosomes by focusing on miRNAs. Myocardial fibrosis was induced in rats using transverse aortic constriction method and handled with exosomes from bone MSCs.

Characterizing Human Mesenchymal Stromal Cells’ Immune-Modulatory Potency Using Targeted Lipidomic Profiling of Sphingolipids

[Cytotherapy] The authors characterized MSCs derived from bone marrow, adipose tissue and umbilical cord tissue for sphingolipids, a class of bioactive lipids, using liquid chromatography/tandem mass spectrometry.

Exosomal Let-7i-5p from Three-Dimensional Cultured Human Umbilical Cord Mesenchymal Stem Cells Inhibits Fibroblast Activation in Silicosis through Targeting TGFBR1

[Ecotoxicology and Environmental Safety] Researchers explored whether human umbilical cord MSC-Exos affected the activation of fibroblasts to alleviate pulmonary fibrosis.

Mesenchymal Stem Cell-Based Treatments for COVID-19: Status and Future Perspectives for Clinical Applications

[Cellular and Molecular Life Sciences] Investigators describe the origins, pathogenesis, and clinical features of COVID-19 and the potential uses of MSCs in therapeutic treatments for severe acute respiratory syndrome coronavirus 2-infected patients.

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