mesenchymal stem cells

[Stem Cell Reviews and Reports] Scientists summarize findings to advocate the reactivation of tumor suppressors p53 and PTEN in glioblastoma treatment and use MSCs as a “Trojan horse” to carry oncolytic viral cargo to disseminated tumor beds.

[Stem Cell Research & Therapy] The authors present a critical analysis of the risks, limitations, challenges, and opportunities that place MSC-based products as a therapeutic strategy that may complement the current arsenal against COVID-19 and reduce the pandemic’s unmet medical needs.

[Stem Cell Research & Therapy] qRT-PCR, western blot, and immunofluorescence staining were performed to evaluate the expression of Mkx and other tendon-associated markers in adipose-derived MSCs and bone marrow-derived MSCs under hypoxia condition.

[Hope Biosciences Stem Cell Research Foundation (BusinessWire, Inc.)] Non-profit research organization Hope Biosciences Stem Cell Research Foundation has received FDA authorization for a randomized, double-blind, single center, Phase II clinical trial to assess the efficacy of multiple intravenous infusions of autologous adipose-derived mesenchymal stem cells in improving symptoms and quality of life in patients with mild-to-moderate multiple sclerosis.

[Stem Cell Research & Therapy] Researchers explored effects of lipopolysaccharide (LPS)-pre extracellular vesicles (EVs) on chondrocyte proliferation, migration, and chondrocyte apoptosis, as well as the protective effect of LPS-pre EVs on mouse articular cartilage.

[Cell and Tissue Research] Investigators devised a strategy to enhance maturation of otic progenitor cells toward human hair cell–like cells by assembling 3D otic organoids that contain human pluripotent stem cell-derived otic cells, endothelial cells, and mesenchymal stem cells.