microglia

[Scientific Reports] Scientists utilized cromolyn, a mast cell inhibitor with anti-inflammatory capabilities, and its fluorinated analogue F-cromolyn to study fibrosis-related protein regulation and secretion downstream of neuroinflammation and their ability to promote microglial phagocytosis and neurite outgrowth.

[Cell Death & Disease] Researchers used a model of cerebral contusion and receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase like knockout (MLKL−/−) mice, and found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue.

[Cell Death Discovery] Researchers evaluated the effects of Pgam5 on neurological deficits and neuroinflammation of controlled cortical impact-induced TBI mouse model in vivo and LPS+ ATP-induced microglia model in vitro.

[Proceedings of the National Academy of Sciences of the United States of America] Microglial ramification, motility, and cytokine release are regulated by tonically active THIK-1 K+ channels on the microglial plasma membrane. Researchers examined whether these channels played a role in phagocytosis.

[EMBO Reports] The authors showed that secreted frizzled-related protein 1 (SFRP1), a multifunctional regulator of cell-to-cell communication, was part of the cellular crosstalk underlying neuroinflammation.

[Journal of Inflammation Research] Investigators recapitulate the molecular basis of bone marrow (BM)MSC-assisted biological processes and summarizes the possible mechanisms related to the interaction between BMMSCs and microglia.