myeloid cells

[International Journal of Laboratory Hematology] The momentum of neutrophil recovery after cord blood varies widely among individuals, but optimal methods to evaluate the momentum of neutrophil recovery and their clinical impacts are yet to be clarified.

[Communications Biology] The antifibrotic effect of auranofin was assessed in thioacetamide- and carbon tetrachloride-induced liver fibrosis models. Hepatic stellate cell, bone marrow-derived macrophage, kupffer cell, and hepatocyte were used to examine the underlying mechanism of auranofin.

[Scientific Reports] Variants of CD33 were associated with Alzheimer’s disease (AD) suggesting that modulation of CD33 signaling might be beneficial in AD. Scientists developed a reliable cellular CD33 reporter systems.

[Scientific Reports] Scientists demonstrated that YIV-906 plus anti-PD1 could eradicate all Hepa 1–6 tumors in all tumor bearing mice. YIV-906 was found to have multiple mechanisms of action to enhance adaptive and innate immunity.

[Journal of Clinical Investigation] Tumor cell SLIT2 knockdown inhibited macrophage invasion and promoted a cytotoxic gene expression profile, which improved tumor vessel function and enhanced efficacy of chemotherapy and immunotherapy.

[Blood] Mice with constitutive activation of mechanistic target of rapamycin complex signaling in osteocytes exhibited a dramatic increase in IL-19 production and promyelocyte/myelocytic expansion, whereas mTORC1 inactivation in osteocytes reduced IL-19 production and neutrophil numbers in mice.