myeloid cells

[Brain] Scientists reported that VEGF signaling at the luminal side of the brain microvasculature played an integral role in the capillary stalling phenomenon of the APP/PS1 mouse model.

[Molecular Therapy-Methods & Clinical Development] In a humanized mouse model under HIV-1 challenge, CXCR4-disrupted CD4+ T cells were enriched in the peripheral blood and spleen, indicating survival advantage due to resistance to viral infection.

[European Respiratory Journal] The authors used a mouse model of concurrent cigarette smoke exposure and H1N1 influenza infection, colony-stimulating factor (CSF)3 supplementation/receptor blockade, and single-cell RNA sequencing to investigate this relationship.

[Nature Communications] Investigators used multi-omics single-cell analysis to probe the dynamic immune responses in hospitalized patients with stable or progressive course of COVID-19, explore V(D)J repertoires, and assess the cellular effects of tocilizumab.

[Acta Biomaterialia] Combination therapy with the transforming growth factor-β receptor I kinase inhibitor SD-208 and a toll-like receptor-7/8 agonist resiquimod was examined along with serum-derived exosomes as versatile carriers and may serve as a promising strategy to treat melanoma and prostate cancer.

[International Journal of Hematology] Investigators encountered a case of human platelet antigen 15 (HPA-15) mismatched cord blood transplantation with a high HPA-15b antibody titer. Prolonged poor graft function and megakaryocyte aplasia with sustained high-titer HPA-15b antibodies were attenuated by rituximab therapy, and rapid recovery of hematopoiesis was achieved.